Document Detail

Depressive symptoms and diet: their effects on prospective inflammation levels in the elderly.
MedLine Citation:
PMID:  22056839     Owner:  NLM     Status:  MEDLINE    
It has been reported that a Mediterranean-type diet in old age is protective against inflammation in Italians with depressive symptoms. In the present study, we explore this hypothesis in a non-Mediterranean, elderly sample, and further disentangle whether it is a Mediterranean diet per se or a healthy diet, in general, that confers this protective effect. The sample is a cohort of people born in 1936, who were assessed on diet and depressive symptoms at age 70. Inflammatory markers, C-reactive protein, fibrinogen and albumin, were collected at ages 70 and 73, while Interleukin-6 transferrin and ferritin were measured at the second time-point only. Controlling for confounding factors (e.g., CVD risk factors, medication) no interaction effect of depressive symptoms and Mediterranean diet was observed on inflammation. However, a main effect of Mediterranean diet on change in C-reactive protein was significant (β=-0.10, p=0.03), and so too was an effect of the 'Health Aware' diet on ferritin (β=-0.12, p=0.02). An interaction between depressive symptoms and a Health Aware diet on transferrin levels showed that there was an association between increased depressive symptoms and inflammation in those following a Health Aware diet. Our results indicate that there are advantages of a Mediterranean diet over a Health Aware diet with respect to the progression of inflammation in old age and that depressive symptoms compound inflammatory burden only for specific biomarkers and under specific dietary conditions unrelated to the Mediterranean diet.
Michelle Luciano; René Mõttus; John M Starr; Geraldine McNeill; Xueli Jia; Leone C A Craig; Ian J Deary
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-28
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  26     ISSN:  1090-2139     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-10-19     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  717-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Alcohol Drinking / metabolism
Body Mass Index
C-Reactive Protein / metabolism
Cohort Studies
Depression / psychology*
Diet, Mediterranean
Ferritins / metabolism
Fibrinogen / metabolism
Inflammation / psychology*
Linear Models
Longitudinal Studies
Motor Activity / physiology
Psychiatric Status Rating Scales
Regression Analysis
Serum Albumin / metabolism
Smoking / metabolism
Socioeconomic Factors
Transferrin / metabolism
Grant Support
G0700704//Medical Research Council; //Biotechnology and Biological Sciences Research Council; //Medical Research Council
Reg. No./Substance:
0/Serum Albumin; 0/Transferrin; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; 9007-73-2/Ferritins

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