| Depressive disorders: focally altered cerebral perfusion measured with arterial spin-labeling MR imaging. | |
| | |
MedLine Citation:
|
PMID: 19401575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To assess focal cerebral perfusion in patients with refractory depressive disorder (RDD), patients with nonrefractory depressive disorder (NDD), and healthy control subjects by using arterial spin-labeling (ASL) magnetic resonance (MR) imaging. MATERIALS AND METHODS: This study was approved by the local ethical committee, and written informed consent was obtained from all participants. Twenty-four patients with RDD, 37 patients with NDD, and 42 healthy control subjects were included. From February 2006 to July 2007, all participants were imaged with a 3-T MR system. ASL and echo-planar images were subtracted and averaged to give perfusion-weighted images. Voxel-based analysis was performed. Region-of-interest analysis was applied to the bilateral hippocampi, thalami, and lentiform nuclei. RESULTS: Patients with NDD showed reduced perfusion in the left prefrontal cortex versus control subjects and increased perfusion mainly in the limbic-striatal areas (P < .05). In contrast, patients with RDD had decreased perfusion predominantly in the bilateral frontal and bilateral thalamic regions (P < .05). Compared with patients with RDD, patients with NDD showed higher perfusion mainly in the limbic-striatal areas (P < .05). In region-of-interest analysis, the NDD group showed higher regional cerebral blood flow than both RDD and control groups in the left hippocampus (P = .045), right hippocampus (P = .001), and right lentiform nucleus (P = .049). CONCLUSION: This study revealed alterations of regional perfusion in the brains of patients with RDD that differed from those in patients with NDD. These results are consistent with the concept that RDD is associated with decreased activity of the bilateral prefrontal areas; and NDD, with decreased activity of left frontal areas in conjunction with overactivity of the bilateral limbic system. |
| | |
Authors:
|
Su Lui; Laura M Parkes; Xiaoqi Huang; Ke Zou; Raymond C K Chan; Hong Yang; Ling Zou; Dongming Li; Hehan Tang; Tijiang Zhang; Xiuli Li; Yi Wei; Long Chen; Xueli Sun; Graham J Kemp; Qi-Yong Gong |
Related Documents
:
|
11030805 - Hemidystonia and hemichoreoathetosis as an initial manifestation of moyamoya disease. 10569215 - Magnetic resonance imaging and angiography in cerebral fungal vasculitis. 2517545 - Lupus anticoagulant as a risk factor for cerebral infarction and habitual abortions. 9332995 - Single photon emission and cerebral computerised tomographic scan and transcranial dopp... 17084065 - Automatic arm removal in pet and ct images for deformable registration. 9256105 - Catheter visualization using locally induced, actively controlled field inhomogeneities. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Radiology Volume: 251 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-29 Completed Date: 2009-05-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
|
Languages: eng Pagination: 476-84 Citation Subset: AIM; IM |
Affiliation:
|
Department of Radiology, Huaxi MR Research Center, State Key Laboratory of Biotherapy, West China Hospital, West China School of Clinical Medicine, Guo Xuexiang 37, Chengdu Sichuan 610041, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Blood Flow Velocity* Brain / blood supply, physiopathology* Cerebral Arteries / physiopathology* Cerebrovascular Circulation* Depressive Disorder / diagnosis*, physiopathology* Female Humans Male Middle Aged Reproducibility of Results Sensitivity and Specificity Spin Labels Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Spin Labels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gadofosveset-enhanced MR angiography of carotid arteries: does steady-state imaging improve accuracy...
Next Document: Multiple sclerosis: hyperintense dentate nucleus on unenhanced T1-weighted MR images is associated w...