Document Detail

Depressive disorder and thyroid axis functioning during pregnancy.
MedLine Citation:
PMID:  19921974     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Depression and thyroid dysfunction are prevalent in women, including pregnant women. The aim of this study was to assess the relationship between depression and thyroid function during pregnancy. METHODS: One hundred and ninety-nine pregnant women three times during pregnancy were assessed for depressive disorder and for thyroid stimulating hormone (TSH) and free thyroxine (FT(4)) concentrations. RESULTS: Prevalence of depressive disorder was 6.5% in early pregnancy, 3.0% in middle pregnancy and 3.5% in late pregnancy. There were no women with overt thyroid dysfunction. Subclinical hyperthyroidism was found in 23% of women in early pregnancy, in 5% of women in middle pregnancy and in 6% of women in late of pregnancy. In late pregnancy depressed women compared to non-depressed women had significantly higher FT(4) concentrations and a strong trend towards lower TSH concentrations as well as higher prevalence of subclinical hyperthyroidism. CONCLUSIONS: These findings show an association between thyroid dysfunction and depression in late pregnancy. Because gestational depression might interfere with pregnancy outcome, evaluation of thyroid function during gestation is warranted.
Robertas Bunevicius; Laima Kusminskas; Narseta Mickuviene; Adomas Bunevicius; Cort A Pedersen; Victor J M Pop
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry     Volume:  10     ISSN:  1814-1412     ISO Abbreviation:  World J. Biol. Psychiatry     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120023     Medline TA:  World J Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  324-9     Citation Subset:  IM    
Institute of Psychophysiology and Rehabilitation, Kaunas University of Medicine, LT-00135 Palanga, Lithuania.
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MeSH Terms
Cross-Sectional Studies
Depressive Disorder / blood*,  diagnosis,  epidemiology
Gestational Age
Hyperthyroidism / blood*,  diagnosis,  epidemiology
Mass Screening
Pregnancy Complications / blood*,  diagnosis,  epidemiology
Thyroid Function Tests*
Thyrotropin / blood*
Thyroxine / blood*
Reg. No./Substance:
7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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