| Depressive disorder and thyroid axis functioning during pregnancy. | |
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MedLine Citation:
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PMID: 19921974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Depression and thyroid dysfunction are prevalent in women, including pregnant women. The aim of this study was to assess the relationship between depression and thyroid function during pregnancy. METHODS: One hundred and ninety-nine pregnant women three times during pregnancy were assessed for depressive disorder and for thyroid stimulating hormone (TSH) and free thyroxine (FT(4)) concentrations. RESULTS: Prevalence of depressive disorder was 6.5% in early pregnancy, 3.0% in middle pregnancy and 3.5% in late pregnancy. There were no women with overt thyroid dysfunction. Subclinical hyperthyroidism was found in 23% of women in early pregnancy, in 5% of women in middle pregnancy and in 6% of women in late of pregnancy. In late pregnancy depressed women compared to non-depressed women had significantly higher FT(4) concentrations and a strong trend towards lower TSH concentrations as well as higher prevalence of subclinical hyperthyroidism. CONCLUSIONS: These findings show an association between thyroid dysfunction and depression in late pregnancy. Because gestational depression might interfere with pregnancy outcome, evaluation of thyroid function during gestation is warranted. |
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Authors:
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Robertas Bunevicius; Laima Kusminskas; Narseta Mickuviene; Adomas Bunevicius; Cort A Pedersen; Victor J M Pop |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry Volume: 10 ISSN: 1814-1412 ISO Abbreviation: World J. Biol. Psychiatry Publication Date: 2009 |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120023 Medline TA: World J Biol Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 324-9 Citation Subset: IM |
Affiliation:
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Institute of Psychophysiology and Rehabilitation, Kaunas University of Medicine, LT-00135 Palanga, Lithuania. rob@ktl.mii.lt |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Sectional Studies Depressive Disorder / blood*, diagnosis, epidemiology Female Gestational Age Humans Hyperthyroidism / blood*, diagnosis, epidemiology Lithuania Mass Screening Pregnancy Pregnancy Complications / blood*, diagnosis, epidemiology Thyroid Function Tests* Thyrotropin / blood* Thyroxine / blood* |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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