Document Detail


Depressive disorder and thyroid axis functioning during pregnancy.
MedLine Citation:
PMID:  19921974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Depression and thyroid dysfunction are prevalent in women, including pregnant women. The aim of this study was to assess the relationship between depression and thyroid function during pregnancy. METHODS: One hundred and ninety-nine pregnant women three times during pregnancy were assessed for depressive disorder and for thyroid stimulating hormone (TSH) and free thyroxine (FT(4)) concentrations. RESULTS: Prevalence of depressive disorder was 6.5% in early pregnancy, 3.0% in middle pregnancy and 3.5% in late pregnancy. There were no women with overt thyroid dysfunction. Subclinical hyperthyroidism was found in 23% of women in early pregnancy, in 5% of women in middle pregnancy and in 6% of women in late of pregnancy. In late pregnancy depressed women compared to non-depressed women had significantly higher FT(4) concentrations and a strong trend towards lower TSH concentrations as well as higher prevalence of subclinical hyperthyroidism. CONCLUSIONS: These findings show an association between thyroid dysfunction and depression in late pregnancy. Because gestational depression might interfere with pregnancy outcome, evaluation of thyroid function during gestation is warranted.
Authors:
Robertas Bunevicius; Laima Kusminskas; Narseta Mickuviene; Adomas Bunevicius; Cort A Pedersen; Victor J M Pop
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry     Volume:  10     ISSN:  1814-1412     ISO Abbreviation:  World J. Biol. Psychiatry     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120023     Medline TA:  World J Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  324-9     Citation Subset:  IM    
Affiliation:
Institute of Psychophysiology and Rehabilitation, Kaunas University of Medicine, LT-00135 Palanga, Lithuania. rob@ktl.mii.lt
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Sectional Studies
Depressive Disorder / blood*,  diagnosis,  epidemiology
Female
Gestational Age
Humans
Hyperthyroidism / blood*,  diagnosis,  epidemiology
Lithuania
Mass Screening
Pregnancy
Pregnancy Complications / blood*,  diagnosis,  epidemiology
Thyroid Function Tests*
Thyrotropin / blood*
Thyroxine / blood*
Chemical
Reg. No./Substance:
7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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