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Depressive Mood and Subsequent Cancer Diagnosis in Patients Undergoing a Colonoscopy.
MedLine Citation:
PMID:  22458989     Owner:  NLM     Status:  Publisher    
BACKGROUND: In patients with clinical signs that may indicate a colorectal cancer, physicians may interpret the presence of a comorbid depressive mood as either increasing or decreasing the likelihood of cancer diagnosis. This study examined the association between depressive mood in candidates for a colonoscopy and subsequent diagnosis of cancer. METHODS: Ninety-four outpatients [35 men, mean age ± standard deviation (SD) = 56.2 ± 9.8 years, 59 women, mean age ± SD = 54.2 ± 12.9 years] were given the 13-item Beck Depression Inventory to assess depressive mood before undergoing a colonoscopy. Additional psychological, demographic, and clinical data were collected prior to the colonoscopy. RESULTS: The colonoscopy found a cancer in 18 patients (19.1%). Cancer patients were older (P = 0.015) and more likely to present with anemia (P < 0.001) and unexplained weight loss (P = 0.046). Depressive mood was associated with a subsequent diagnosis of cancer in women (P = 0.007), but not in men (P = 0.985). This association remained significant after adjustment for potential confounders in women (i.e. anemia and unexplained weight loss) (P = 0.014). CONCLUSIONS: In women with clinical signs that warrant a colonoscopy, comorbid depressive mood may be associated with an increased likelihood of colorectal cancer and should not delay the receipt of a guideline-based diagnosis procedure.
Gaëlle Abgrall-Barbry; Cédric Lemogne; Dominique Lamarque; Bérengère Leuret; Sarah Bydlowski; Raymond Jian; Nicolas Dantchev; Silla M Consoli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-27
Journal Detail:
Title:  Psychosomatics     Volume:  -     ISSN:  1545-7206     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376506     Medline TA:  Psychosomatics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.
Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine, Paris, France; Assistance Publique-Hôpitaux de Paris, Department of Psychiatry, Hôtel-Dieu Hospital, Paris, France.
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