| Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity. | |
| | |
MedLine Citation:
|
PMID: 22020230 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Unipolar depression and diabetes mellitus each account for a significant proportion of the global burden of disease. Epidemiological literature suggests a bi-directional relationship between these two common disorders, and evidence from the molecular sciences supports a role for inflammation in the pathogenesis and pathophysiology of each disorder individually. Recent advances in understanding the neurobiology of depression have implicated dysfunction of the hypothalamus-pituitary-adrenal axis, neurotrophins, and inflammatory mediators in the development of this disorder. Similarly, dysregulated facets of both the innate and adaptive immune system have been implicated in the onset of insulin resistance and type 2 diabetes. This review draws upon an emerging body of epidemiological and mechanistic evidence to support the hypothesis that shared inflammatory mechanisms may represent a key biological link in this co-morbidity. Given the shared mechanisms of this co-morbidity, these patients may be excellent candidates for novel immune targeted pharmacotherapy. |
| | |
Authors:
|
Michael J Stuart; Bernhard T Baune |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-14 |
Journal Detail:
|
Title: Neuroscience and biobehavioral reviews Volume: - ISSN: 1873-7528 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7806090 Medline TA: Neurosci Biobehav Rev Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
|
James Cook University, School of Medicine and Dentistry, 101 Angus Smith Drive, Townsville, Queensland 4811, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Systematic review of biomonitoring studies to determine the association between exposure to organoph...
Next Document: EEG delta oscillations as a correlate of basic homeostatic and motivational processes.