Document Detail

Depression, smoking abstinence and HPA function in women smokers.
MedLine Citation:
PMID:  15378674     Owner:  NLM     Status:  MEDLINE    
To determine whether smokers with a history of depression are differentially susceptible to smoking withdrawal, depressed mood induction and/or hypothalamic-pituitary-adrenal (HPA) axis dysregulation during smoking abstinence, 24 women smokers with and without such a history were studied. During one 5-day interval, participants smoked ad libitum; during a second they abstained. On day 4, the participants were exposed to the Velten mood induction procedure (VMIP). Participants were then instructed to take 1 mg dexamethasone at 11 pm. At 4 pm on day 5, blood samples were withdrawn to determine the cortisol and ACTH response. Despite lower baseline cotinine levels, history-positive participants displayed more pronounced overall withdrawal distress than did history-negative participants, regardless of condition. The VMIP increased depression as well as negative responses on other profile of mood states subscales. Despite many overall group differences, no significant main effects for smoking condition nor interaction effects emerged. All participants evinced cortisol suppression in response to dexamethasone during both conditions, but the degree of suppression did not differ as a function of either abstinence or depression history. In history-positive smokers, however, ACTH levels trended toward overall elevation and showed almost no suppression during abstinence; thus exacerbation of HPA dysregulation in history-positive smokers during smoking abstinence cannot be ruled out.
Ovide F Pomerleau; Cynthia S Pomerleau; Sandy M Snedecor; Stefanie Gaulrapp; Rebecca Namenek Brouwer; Oliver G Cameron
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human psychopharmacology     Volume:  19     ISSN:  0885-6222     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2005-01-12     Revised Date:  2008-03-06    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  467-76     Citation Subset:  IM    
Copyright Information:
2004 John Wiley & Sons, Ltd.
Department of Psychiatry, Nicotine Research Laboratory, University of Michigan, Ann Arbor, MI 48105, USA.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Depression / psychology*
Hydrocortisone / blood
Hypothalamo-Hypophyseal System / physiopathology*
Middle Aged
Pituitary-Adrenal System / physiopathology*
Substance Withdrawal Syndrome / physiopathology,  psychology
Tobacco Use Disorder / physiopathology,  psychology*
Grant Support
Reg. No./Substance:
50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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