Document Detail

Depression and the risk of psoriasis in US women.
MedLine Citation:
PMID:  23030685     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Depression is a common mental health condition that has been associated with psoriasis. In the absence of prospective data, it remains unclear whether depression precedes psoriasis as a risk factor.
OBJECTIVES: To examine the association between depression and the risk of new-onset psoriasis.
METHODS: A prospective cohort of 86 880 US female nurses, The Nurses' Health Study II, was followed up from 1993 to 2005. Participants reported anti-depressant use and completed the Mental Health Index (MHI), a subscale of the Short-Form 36 in 1993. The MHI assessed for depression and scores was categorized into four strata: 0-52, 53-75, 76-85 and 86-100, with lower scores associated with increasing depressive symptoms. We excluded participants with a history of psoriasis prior to 1993. A self-report of incident physician-diagnosed psoriasis constituted the main outcome measure. For a sensitivity analysis, we had a subset of confirmed psoriasis cases.
RESULTS: Depression was associated with an increased risk of incident psoriasis. Compared to women in the non-depressed group (MHI 86-100), women who reported either having high depressive symptomatology (MHI scores < 52) or who were on anti-depressants had a multivariate relative risk (RR) of 1.59 for developing subsequent psoriasis (95% confidence interval [CI], 1.21-2.08). These associations became stronger among confirmed psoriasis cases.
CONCLUSIONS: We found that depression was independently associated with an increased risk of psoriasis in this population of US women.
P L Dominguez; J Han; T Li; A Ascherio; A A Qureshi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-03
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  27     ISSN:  1468-3083     ISO Abbreviation:  J Eur Acad Dermatol Venereol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-07-29     Completed Date:  2013-10-28     Revised Date:  2014-10-19    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1163-7     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.
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MeSH Terms
Depression / complications*
Prospective Studies
Psoriasis / epidemiology*,  etiology*
Risk Factors
United States
Grant Support

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