| Depression, posttraumatic stress disorder, and mortality. | |
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MedLine Citation:
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PMID: 17991816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether a history of depression and/or posttraumatic stress disorder (PTSD) is associated with all-cause mortality in primary care patients over an average of 2 years. METHODS: Patients from seven Department of Veterans Affairs medical centers completed mailed questionnaires. Depression and PTSD status were determined from patient self-report of a prior diagnosis and/or electronic administrative data. Date of death was ascertained from Veterans Health Information Systems and Technology Architecture and the Department of Veterans Affairs' Beneficiary Identification and Records Locator System. RESULTS: Among 35,715 primary care patients, those with a history of depression without a history of PTSD (n = 6876) were at increased risk of death over an average of 2 years compared with patients with neither depression nor PTSD after adjustment for demographic variables, health behaviors, and medical comorbidity (hazard ratio (HR) = 1.17; 95% Confidence Interval (CI) = 1.06-1.28). However, patients with a history of PTSD without a history of depression (n = 748) were not at increased risk of death compared with patients with neither depression nor PTSD (HR = 0.84; 95% CI = 0.63-1.13). Patients with a history of both (n = 3762) were at increased risk of death after adjustment for demographic factors, although not after additional adjustment for health behaviors and medical comorbidity (HR = 0.90; 95% CI = 0.78-1.04). CONCLUSIONS: In a large sample of veterans, a prior diagnosis of depression, but not PTSD, was associated with an increased risk of death over an average of 2 years after adjusting for age, demographic variables, health behaviors, and medical comorbidity. |
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Authors:
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Leslie S Kinder; Katharine A Bradley; Wayne J Katon; Evette Ludman; Mary B McDonell; Chris L Bryson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-11-08 |
Journal Detail:
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Title: Psychosomatic medicine Volume: 70 ISSN: 1534-7796 ISO Abbreviation: Psychosom Med Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-15 Completed Date: 2008-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: United States |
Other Details:
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Languages: eng Pagination: 20-6 Citation Subset: IM |
Affiliation:
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Health Services Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA. lskinder@stanfordalumni.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cohort Studies Comorbidity Depression / mortality* Female Humans Male Middle Aged Primary Health Care / statistics & numerical data Risk Factors Stress Disorders, Post-Traumatic / mortality* United States / epidemiology Veterans / psychology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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