Document Detail

Depression, posttraumatic stress disorder, and mortality.
MedLine Citation:
PMID:  17991816     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether a history of depression and/or posttraumatic stress disorder (PTSD) is associated with all-cause mortality in primary care patients over an average of 2 years. METHODS: Patients from seven Department of Veterans Affairs medical centers completed mailed questionnaires. Depression and PTSD status were determined from patient self-report of a prior diagnosis and/or electronic administrative data. Date of death was ascertained from Veterans Health Information Systems and Technology Architecture and the Department of Veterans Affairs' Beneficiary Identification and Records Locator System. RESULTS: Among 35,715 primary care patients, those with a history of depression without a history of PTSD (n = 6876) were at increased risk of death over an average of 2 years compared with patients with neither depression nor PTSD after adjustment for demographic variables, health behaviors, and medical comorbidity (hazard ratio (HR) = 1.17; 95% Confidence Interval (CI) = 1.06-1.28). However, patients with a history of PTSD without a history of depression (n = 748) were not at increased risk of death compared with patients with neither depression nor PTSD (HR = 0.84; 95% CI = 0.63-1.13). Patients with a history of both (n = 3762) were at increased risk of death after adjustment for demographic factors, although not after additional adjustment for health behaviors and medical comorbidity (HR = 0.90; 95% CI = 0.78-1.04). CONCLUSIONS: In a large sample of veterans, a prior diagnosis of depression, but not PTSD, was associated with an increased risk of death over an average of 2 years after adjusting for age, demographic variables, health behaviors, and medical comorbidity.
Leslie S Kinder; Katharine A Bradley; Wayne J Katon; Evette Ludman; Mary B McDonell; Chris L Bryson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-11-08
Journal Detail:
Title:  Psychosomatic medicine     Volume:  70     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-15     Completed Date:  2008-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-6     Citation Subset:  IM    
Health Services Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
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MeSH Terms
Cohort Studies
Depression / mortality*
Middle Aged
Primary Health Care / statistics & numerical data
Risk Factors
Stress Disorders, Post-Traumatic / mortality*
United States / epidemiology
Veterans / psychology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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