Document Detail

Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete.
MedLine Citation:
PMID:  16465199     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Only one study has investigated the relationship of essential fatty acids in the adipose tissue with depression in adults and suggested an inverse relationship between docosahexaenoic acid (22:6 n-3) (DHA) and depression. OBJECTIVE: To examine the relation between adipose tissue polyunsaturated fatty acids especially n-3 and n-6 fatty acids, an index of long-term or habitual fatty acid intake, and depression in adults. DESIGN: Cross-sectional study of healthy adults from the island of Crete. SETTING: The Preventive Medicine and Nutrition Clinic, University of Crete, Greece. SUBJECTS: A total of 130 healthy adults (59 males, 71 females) aged 22-58 years. The sample was a sub-sample of the Greek ApoEurope study group. METHODS: Fatty acids were determined by gas chromatography in adipose tissue. Information about depression was obtained through the Zung Self-rating Depression Scale. RESULTS: Adipose tissue DHA was inversely related with depression. Multiple linear regression analysis taking into account the possible confounding effect of age, gender, body mass index, smoking and educational level confirmed this association. CONCLUSIONS: The inverse relationship between adipose DHA and depression in adults, replicates findings of a previous study. This relationship indicates that a low long-term dietary intake of DHA is associated with an increased risk for depression in adults.
G Mamalakis; N Kalogeropoulos; N Andrikopoulos; C Hatzis; D Kromhout; J Moschandreas; A Kafatos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-08
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  60     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  882-8     Citation Subset:  IM    
Department of Social Medicine Preventive Medicine and Nutrition, School of Medicine, University of Crete, Iraklion, Crete, Greece.
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MeSH Terms
Adipose Tissue / chemistry*,  metabolism
Age Factors
Body Mass Index
Chromatography, Gas / methods
Cross-Sectional Studies
Depression / epidemiology*
Dietary Fats, Unsaturated / administration & dosage*,  metabolism
Docosahexaenoic Acids / analysis
Fatty Acids, Omega-3 / analysis*
Food Habits
Greece / epidemiology
Linear Models
Middle Aged
Sex Factors
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-3; 25167-62-8/Docosahexaenoic Acids

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