Document Detail

Depression in headaches: chronification.
MedLine Citation:
PMID:  22547099     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Recent evidence supports the suggestion that migraine is a chronic disorder with episodic attacks that increase in frequency in a subgroup of patients, transforming migraine into a refractory chronic condition with poor outcome and severe impact. Among the risk factors for migraine chronification depression figures notably. Early diagnosis and management of risk factors in migraineurs prevent migraine chronification and its consequences. The scope of this article is to review depression as a potential cofactor for migraine chronification.
RECENT FINDINGS: Population-based studies revealed that migraineurs often have symptoms of depression, with strongest associations for migraine with aura. Patients with depression also have an increased risk for migraine, migraine with aura in particular. Twin studies showed similar findings. This bidirectional relationship suggests that migraine and depression may share common causative factors, possibly genetically determined, that might control migraine chronification. Migraine patients may develop depression as a result of the demoralizing experience of recurrent and disabling headaches and depressed patients may develop migraine because of increased pain sensitivity, in the basis of a common genetic background.
SUMMARY: We suggest that clinicians consider depression as part of migraine management in order to optimize treatment and avoid migraine progression.
Christina I Deligianni; Michail Vikelis; Dimos D Mitsikostas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  25     ISSN:  1473-6551     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-01     Completed Date:  2012-08-31     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Neurology Department, Athens Naval Hospital, Athens, Greece.
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MeSH Terms
Chronic Disease
Depression / epidemiology,  etiology*
Headache / complications*,  epidemiology,  psychology*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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