Document Detail

Depression, heart disease, and tricyclic antidepressants.
MedLine Citation:
PMID:  2661547     Owner:  NLM     Status:  MEDLINE    
Concern over the cardiovascular effects of tricyclic antidepressants has been long standing. Recently there have been a number of studies of the use of tricyclics in depressed patients with preexisting cardiac disease, specifically ventricular arrhythmias, impairment of left ventricular function, and conduction disease. The results have demonstrated that tricyclics are effective Class 1A antiarrhythmic drugs and that contrary to earlier expectations tricyclics do not have a deleterious effect on left ventricular function even in patients with severe preexisting left ventricular impairment, but that patients with bundle-branch block are at increased risk to develop significant conduction complications when treated with a tricyclic. Further, patients with affective disorder may have a higher rate of mortality from cardiac disease compared with normal controls; recent data on heart rate variability abnormalities in depressed patients may be a first clue to the mechanism underlying that increased risk.
S P Roose; A H Glassman; G W Dalack
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  50 Suppl     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-10     Completed Date:  1989-08-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  12-6; discussion 17     Citation Subset:  IM    
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York.
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MeSH Terms
Antidepressive Agents, Tricyclic / adverse effects,  therapeutic use*
Arrhythmias, Cardiac / complications,  drug therapy
Bundle-Branch Block / complications
Depressive Disorder / complications,  drug therapy*
Heart Diseases / complications*,  drug therapy,  mortality
Risk Factors
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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