| Depression, heart disease, and tricyclic antidepressants. | |
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MedLine Citation:
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PMID: 2661547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Concern over the cardiovascular effects of tricyclic antidepressants has been long standing. Recently there have been a number of studies of the use of tricyclics in depressed patients with preexisting cardiac disease, specifically ventricular arrhythmias, impairment of left ventricular function, and conduction disease. The results have demonstrated that tricyclics are effective Class 1A antiarrhythmic drugs and that contrary to earlier expectations tricyclics do not have a deleterious effect on left ventricular function even in patients with severe preexisting left ventricular impairment, but that patients with bundle-branch block are at increased risk to develop significant conduction complications when treated with a tricyclic. Further, patients with affective disorder may have a higher rate of mortality from cardiac disease compared with normal controls; recent data on heart rate variability abnormalities in depressed patients may be a first clue to the mechanism underlying that increased risk. |
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Authors:
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S P Roose; A H Glassman; G W Dalack |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of clinical psychiatry Volume: 50 Suppl ISSN: 0160-6689 ISO Abbreviation: J Clin Psychiatry Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-08-10 Completed Date: 1989-08-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801243 Medline TA: J Clin Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 12-6; discussion 17 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antidepressive Agents, Tricyclic
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adverse effects,
therapeutic use* Arrhythmias, Cardiac / complications, drug therapy Bundle-Branch Block / complications Depressive Disorder / complications, drug therapy* Heart Diseases / complications*, drug therapy, mortality Humans Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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