Document Detail

Depression of factor XII-dependent fibrinolytic activity characterizes patients with early myocardial reinfarction after recombinant tissue-type plasminogen activator therapy.
MedLine Citation:
PMID:  1906904     Owner:  NLM     Status:  MEDLINE    
Twenty patients with acute myocardial infarction treated with recombinant tissue-type plasminogen activator (rt-PA) had endogenous factor XII-dependent fibrinolytic activity levels measured throughout the hospital period and those levels were prospectively correlated with the incidence of recurrent myocardial infarction until 8 weeks after hospital discharge. Within the follow-up period, recurrent myocardial infarction was observed in 8 patients, whereas the remaining 12 patients showed no clinical evidence of recurrence. The patients in the reinfarction group were characterized by a more pronounced depletion of and sustained lower levels of factor XII-dependent fibrinolytic activity than were the patients with no reinfarction (p less than 0.05). The decrease in fibrinolytic activity during rt-PA therapy was significantly associated with a depletion of functional alpha 2-antiplasmin, the primary plasmin inhibitor. These results indicate that, paradoxically, coronary thrombolysis with rt-PA involves depletion of endogenous factor XII-dependent fibrinolytic activity levels, which constitutes a risk for early myocardial reinfarction.
S Munkvad; J Jespersen; J Gram; C Kluft
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  18     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-26     Completed Date:  1991-08-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  454-8     Citation Subset:  AIM; IM    
Department of Clinical Chemistry, Ribe County Hospital, Esbjerg, Denmark.
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MeSH Terms
Factor XII / analysis*
Middle Aged
Myocardial Infarction / blood,  drug therapy*,  epidemiology
Recombinant Proteins / therapeutic use
Thrombolytic Therapy*
Tissue Plasminogen Activator / therapeutic use*
alpha-2-Antiplasmin / analysis
Reg. No./Substance:
0/Recombinant Proteins; 0/alpha-2-Antiplasmin; 9001-30-3/Factor XII; EC Plasminogen Activator

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