Document Detail


Depression is associated with decreased blood pressure, but antidepressant use increases the risk for hypertension.
MedLine Citation:
PMID:  19237679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study compared blood pressure levels between subjects with clinical anxiety and depressive disorders with healthy controls. Cross-sectional data were obtained in a large cohort study, the Netherlands Study of Depression and Anxiety (N=2981). Participants were classified as controls (N=590) or currently or remittedly depressed or anxious subjects (N=2028), of which 1384 were not and 644 were using antidepressants. Regression analyses calculated the contributions of anxiety and depressive disorders and antidepressant use to diastolic and systolic blood pressures, after controlling for multiple covariates. Heart rate and heart rate variability measures were subsequently added to test whether effects of anxiety/depression or medication were mediated by vagal control over the heart. Higher mean diastolic blood pressure was found among the current anxious subjects (beta=0.932; P=0.03), although anxiety was not significantly related to hypertension risk. Remitted and current depressed subjects had a lower mean systolic blood pressure (beta=-1.74, P=0.04 and beta=-2.35, P=0.004, respectively) and were significantly less likely to have isolated systolic hypertension than controls. Users of tricyclic antidepressants had higher mean systolic and diastolic blood pressures and were more likely to have hypertension stage 1 (odds ratio: 1.90; 95% CI: 0.94 to 3.84; P=0.07) and stage 2 (odds ratio: 3.19; 95% CI: 1.35 to 7.59; P=0.008). Users of noradrenergic and serotonergic working antidepressants were more likely to have hypertension stage 1. This study shows that depressive disorder is associated with low systolic blood pressure and less hypertension, whereas the use of certain antidepressants is associated with both high diastolic and systolic blood pressures and hypertension.
Authors:
Carmilla M M Licht; Eco J C de Geus; Adrie Seldenrijk; Hein P J van Hout; Frans G Zitman; Richard van Dyck; Brenda W J H Penninx
Related Documents :
20213929 - Early vascular phenotypes in the genesis of hypertension.
12107419 - The 2001 canadian recommendations for the management of hypertension: part one--assessm...
22524589 - Haemodynamic stability and pulmonary shunt during spontaneous breathing and mechanical ...
19804249 - Effects of caffeine and coffee consumption on cardiovascular disease and risk factors.
8853639 - Relationships of the circadian rhythms of thrombotic, ischemic, hemorrhagic, and arrhyt...
22288309 - Suspect carbon dioxide embolism during retroperitoneoscopic adrenalectomy.
19498339 - Relationship between blood pressure and anthropometry in a cohort of brazilian men: a c...
21762559 - Airway pressure release ventilation: what do we know?
7836209 - Acute lung injury isolated to an in situ lung preparation causes sustained reflex cardi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-23
Journal Detail:
Title:  Hypertension     Volume:  53     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-04-22     Revised Date:  2009-06-18    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  631-8     Citation Subset:  IM    
Affiliation:
Vrije Universiteit Medical Center, Department of Psychiatry, AJ Ernststraat 887, 1081 HL, Amsterdam, The Netherlands. C.Licht@vumc.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antidepressive Agents / administration & dosage,  adverse effects*
Anxiety Disorders / drug therapy,  epidemiology
Autonomic Nervous System / drug effects
Blood Pressure / drug effects*
Cross-Sectional Studies
Depressive Disorder / drug therapy*,  epidemiology*
Female
Heart Rate / drug effects
Humans
Hypertension / epidemiology*
Linear Models
Logistic Models
Male
Middle Aged
Prevalence
Risk Factors
Young Adult
Chemical
Reg. No./Substance:
0/Antidepressive Agents
Comments/Corrections
Comment In:
Hypertension. 2009 Jul;54(1):e1; author reply e2   [PMID:  19451412 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy.
Next Document:  Arterial pulse wave velocity and cognition with advancing age.