Document Detail


Depression as a potential modulator of Beta-adrenergic-associated leukocyte mobilization in heart failure patients.
MedLine Citation:
PMID:  21070923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: the aim of this study was to determine whether depressive symptoms are related to alterations in the sensitivity of peripheral blood mononuclear cells to β-adrenergic agonists in patients with heart failure (HF) by measuring in vitro chemotaxis (CTX) to isoproterenol at rest and after acute exercise in patients with HF and controls.
BACKGROUND: clinical outcomes are worse for patients with HF presenting with symptoms of depression. Sympathetically modulated immune dysregulation associated with depression may be one mechanism leading to worse prognosis.
METHODS: seventy-seven patients with HF and 44 controls (mean age 56.4 ± 1.3 years) completed the Beck Depression Inventory and a 15-min mild-graded exercise task on a stationary bicycle. Exercise intensity was kept relative to fitness levels for all participants by gradually increasing resistance to reach a Borg scale subjective rating of 12 to 13, "somewhat hard." Plasma norepinephrine and epinephrine levels were measured before and after exercise. Chemotaxis to isoproterenol was determined by measuring in vitro peripheral blood mononuclear cell migration through a modified Boyden chamber.
RESULTS: In patients with HF, depressive symptom severity was associated with greater CTX after exercise (p = 0.001). Higher resting norepinephrine in patients with HF was also associated with increased CTX to exercise (p = 0.03).
CONCLUSIONS: patients with HF with higher depressive symptoms and norepinephrine exhibited increased peripheral blood mononuclear cell CTX to isoproterenol to mild exercise, suggesting greater β-adrenergic sensitivity. Increased immune migration in patients with HF who have elevated depressive symptoms could be associated with cardiac remodeling and HF disease progression.
Authors:
Laura S Redwine; Petra H Wirtz; Suzi Hong; Jos A Bosch; Jos Bosch; Michael G Ziegler; Barry Greenberg; Paul J Mills
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  56     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-12     Completed Date:  2011-01-11     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1720-7     Citation Subset:  AIM; IM    
Copyright Information:
2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / therapeutic use*
Adult
Aged
Aged, 80 and over
Chemotaxis / drug effects*
Depression / blood,  diagnosis,  etiology*
Disease Progression
Epinephrine / blood
Exercise Test
Female
Follow-Up Studies
Heart Failure / blood*,  complications,  drug therapy
Humans
Isoproterenol / therapeutic use*
Leukocytes, Mononuclear / drug effects,  metabolism*
Male
Middle Aged
Norepinephrine / blood
Prognosis
Retrospective Studies
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
HL-073355/HL/NHLBI NIH HHS; HL-57265/HL/NHLBI NIH HHS; R01 HL073355/HL/NHLBI NIH HHS; R01 HL073355-01A2/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; L628TT009W/Isoproterenol; X4W3ENH1CV/Norepinephrine; YKH834O4BH/Epinephrine
Comments/Corrections
Erratum In:
J Am Coll Cardiol. 2011 May 10;57(19):1960
Note: Bosch, Jos [corrected to Bosch, Jos A]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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