| Depression as a potential modulator of Beta-adrenergic-associated leukocyte mobilization in heart failure patients. | |
| | |
MedLine Citation:
|
PMID: 21070923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: the aim of this study was to determine whether depressive symptoms are related to alterations in the sensitivity of peripheral blood mononuclear cells to β-adrenergic agonists in patients with heart failure (HF) by measuring in vitro chemotaxis (CTX) to isoproterenol at rest and after acute exercise in patients with HF and controls. BACKGROUND: clinical outcomes are worse for patients with HF presenting with symptoms of depression. Sympathetically modulated immune dysregulation associated with depression may be one mechanism leading to worse prognosis. METHODS: seventy-seven patients with HF and 44 controls (mean age 56.4 ± 1.3 years) completed the Beck Depression Inventory and a 15-min mild-graded exercise task on a stationary bicycle. Exercise intensity was kept relative to fitness levels for all participants by gradually increasing resistance to reach a Borg scale subjective rating of 12 to 13, "somewhat hard." Plasma norepinephrine and epinephrine levels were measured before and after exercise. Chemotaxis to isoproterenol was determined by measuring in vitro peripheral blood mononuclear cell migration through a modified Boyden chamber. RESULTS: In patients with HF, depressive symptom severity was associated with greater CTX after exercise (p = 0.001). Higher resting norepinephrine in patients with HF was also associated with increased CTX to exercise (p = 0.03). CONCLUSIONS: patients with HF with higher depressive symptoms and norepinephrine exhibited increased peripheral blood mononuclear cell CTX to isoproterenol to mild exercise, suggesting greater β-adrenergic sensitivity. Increased immune migration in patients with HF who have elevated depressive symptoms could be associated with cardiac remodeling and HF disease progression. |
| | |
Authors:
|
Laura S Redwine; Petra H Wirtz; Suzi Hong; Jos A Bosch; Jos Bosch; Michael G Ziegler; Barry Greenberg; Paul J Mills |
Related Documents
:
|
10084063 - Frequency domain heart rate variability and plasma norepinephrine level in the coronary... 8746903 - Autonomic balance in patients with angina and a normal coronary angiogram. 6342353 - Efficacy of prazosin in the management of chronic congestive heart failure: a 6-month r... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 56 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-12 Completed Date: 2011-01-11 Revised Date: 2011-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1720-7 Citation Subset: AIM; IM |
Copyright Information:
|
2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Psychiatry, University of California, San Diego, La Jolla, California 92161, USA. lredwine@ucsd.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Agonists
/
therapeutic use* Adult Aged Aged, 80 and over Chemotaxis / drug effects* Depression / blood, diagnosis, etiology* Disease Progression Epinephrine / blood Exercise Test Female Follow-Up Studies Heart Failure / blood*, complications, drug therapy Humans Isoproterenol / therapeutic use* Leukocytes, Mononuclear / drug effects, metabolism* Male Middle Aged Norepinephrine / blood Prognosis Retrospective Studies Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
|
HL-073355/HL/NHLBI NIH HHS; HL-57265/HL/NHLBI NIH HHS; R01 HL073355-01A2/HL/NHLBI NIH HHS; R01 HL073355-07/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Agonists; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7683-59-2/Isoproterenol |
| Comments/Corrections | |
Erratum In:
|
J Am Coll Cardiol. 2011 May 10;57(19):1960 Note: Bosch, Jos [corrected to Bosch, Jos A] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of conventional cardiovascular risk factors and multiple biomarkers for the prediction of...
Next Document: Roles of the left atrial roof and pulmonary veins in the anatomic substrate for persistent atrial fi...