Document Detail

Depression and acute myocardial infarction.
MedLine Citation:
PMID:  15133376     Owner:  NLM     Status:  MEDLINE    
A number of studies have demonstrated a relationship between depression and low perceived social support and increased cardiac morbidity and mortality in patients with coronary heart disease. There is also evidence that depression increases the risk of acute myocardial infarction and morbidity and mortality following it. This review examines those studies that have investigated these relationships as well as those that have attempted to explain them on the basis of various pathophysiologic mechanisms. Among the latter are studies that have shown that selective serotonin reuptake inhibitors are beneficial in the treatment of depression and that they appear to reverse the enhanced platelet activity observed in depressed patients with acute myocardial infarction. Depression increases hospital length of stay, procedures, readmission rates, and the cost of medical care. Much remains to be elucidated concerning the roles of depression and low perceived social support in predisposing to acute myocardial infarction and to increased morbidity and mortality following it. However, sufficient scientific evidence exists for physicians to make efforts to diagnose and treat depression to reduce the concurrent risk of acute myocardial infarction and morbidity and mortality following it.
Monte Malach; Pascal James Imperato
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Preventive cardiology     Volume:  7     ISSN:  1520-037X     ISO Abbreviation:  Prev Cardiol     Publication Date:  2004  
Date Detail:
Created Date:  2004-05-10     Completed Date:  2004-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9813731     Medline TA:  Prev Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-90; quiz 91-2     Citation Subset:  IM    
IPRO, Lake Success, NY 11042, USA.
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MeSH Terms
Coronary Disease / economics,  epidemiology,  psychology,  therapy
Costs and Cost Analysis
Depressive Disorder* / complications,  economics,  epidemiology,  therapy
Myocardial Infarction* / economics,  epidemiology,  psychology,  therapy

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