| Depression-executive dysfunction syndrome relates to poor poststroke survival. | |
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MedLine Citation:
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PMID: 20808085 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to investigate the influence of poststroke depression and executive dysfunction on long-term survival after acute stroke. METHODS: A total of 257 consecutive acute ischemic stroke patients were included in the study and followed up to 12 years. Depression was diagnosed 3 months after stroke in 99 patients (38.5%). FINDINGS: In Kaplan-Meier analysis, there was no difference in survival of patients with and without poststroke depression (8.7 versus 8.3 years). Instead, patients with both depression and executive dysfunction had shorter median survival than patients with neither depression nor executive dysfunction (6.6 versus 10.3 years). Comparison between all patients with executive dysfunction and patients without it, not regarding depressive status, showed that executive dysfunction in itself was strongly associated with poor poststroke survival (6.4 versus 10.6 years). In stepwise Cox regression proportional hazards analysis adjusted with covariates, poststroke depression with executive dysfunction (hazard ratio [HR] 1.63) and advanced age (HR 1.11) remained as independent predictors of poor long-term survival. INTERPRETATION: The authors' well-defined poststroke cohort with long-term follow-up indicates that in poststroke depression, the depression-executive dysfunction syndrome is the predictor of poor long-term survival rather than depression in itself. |
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Authors:
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Susanna Melkas; Risto Vataja; Niku K J Oksala; Hanna Jokinen; Tarja Pohjasvaara; Anni Oksala; Antero Leppävuori; Markku Kaste; Pekka J Karhunen; Timo Erkinjuntti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry Volume: 18 ISSN: 1545-7214 ISO Abbreviation: Am J Geriatr Psychiatry Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9309609 Medline TA: Am J Geriatr Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 1007-16 Citation Subset: IM |
Affiliation:
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Department of Neurology, Helsinki University Central Hospital, Finland. susanna.melkas@hus.fi |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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