Document Detail


Depressant effect of trapidil on dog coronary arterial contraction induced by ergonovine.
MedLine Citation:
PMID:  7265467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of trapidil on ergonovine-induced contractions of isolated dog coronary arteries were investigated in vitro. Ergonovine produced dose-dependent contractions of helical strips cut from the left circumflex branches of coronary arteries. Trapidil significantly depressed these-contractions. 5-HT also produced dose-dependent contractions of the strips, which were depressed by trapidil. In isolated rabbit femoral arterial preparations, norepinephrine dose-dependently contracted the strips. Phentolamine significantly depressed these contractions, and trapidil depressed them when relatively high doses were applied previously. Results indicate that trapidil has a depressant effect on coronary arterial contractions induced by ergonovine, partly through antagonism to 5-HT receptor and/or adrenergic alpha receptor.
Authors:
M Sakanashi; Y Yoshikawa; G Kondoh; K Yonemura
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese heart journal     Volume:  22     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  413-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / drug effects
Coronary Vessels / drug effects*
Dogs
Dose-Response Relationship, Drug
Ergonovine / antagonists & inhibitors*,  pharmacology
Norepinephrine / pharmacology
Pyrimidines / pharmacology*
Rabbits
Trapidil / pharmacology*
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
0/Pyrimidines; 15421-84-8/Trapidil; 51-41-2/Norepinephrine; 60-79-7/Ergonovine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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