Document Detail

Depot pipotiazine 1970-1982: a review.
MedLine Citation:
PMID:  6134718     Owner:  NLM     Status:  MEDLINE    
In the past 14 years pipotiazine palmitate, the second oldest depot neuroleptic, has proven to be effective and safe in reducing and preventing resurgence of symptoms of acute and chronic psychoses, chiefly in schizophrenia. It is particularly valuable in the management of erratic ingestors and unreliable absorbers of oral neuroleptics. Clinical experience substantiates that pipotiazine palmitate therapy is best initiated at low doses (25 mg), and that the most effective maintenance dosage is 25 to 200 mg once a month. Pipotiazine palmitate has a low propensity to evoke extrapyramidal reactions; in fact, it causes the lowest incidence of EPS of all depot neuroleptics. Patients receiving pipotiazine palmitate seldom require concomitant antiparkinsonian medication. This review highlights other assets and liabilities of depot pipotiazine therapy.
E A Burch; F J Ayd
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  44     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-7     Citation Subset:  IM    
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MeSH Terms
Antipsychotic Agents / therapeutic use*
Basal Ganglia Diseases
Chemical Phenomena
Delayed-Action Preparations
Drug Administration Schedule
Dyskinesia, Drug-Induced / etiology
Middle Aged
Psychotic Disorders / drug therapy*,  psychology
Schizophrenia / drug therapy
Seizures / chemically induced
Thiazines / administration & dosage,  adverse effects,  therapeutic use*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Delayed-Action Preparations; 0/Phenothiazines; 0/Thiazines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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