Document Detail

Depot neuroleptic medication and serum levels by radioreceptor assay: prolactin concentration, electrocardiogram abnormalities and six-month outcome.
MedLine Citation:
PMID:  3435373     Owner:  NLM     Status:  MEDLINE    
Twenty-six chronic schizophrenic patients on well-established depot neuroleptic regimes with stable doses (16 on fluphenazine decanoate, 10 on flupenthixol decanoate) had serum neuroleptic levels measured by radioreceptor assay (RRA) and were followed for six months. The serum prolactin (PRL) concentration and resting electrocardiogram (ECG) were also taken at the beginning of the study period. Correlations had previously been noted between RRA measured neuroleptic levels and outcome in both acute and chronic patients on oral medication. However, in this study of depot medication no significant correlations were found between serum neuroleptic concentration, serum prolactin concentration and the clinical state or outcome. The prevalence (33%) and type of ECG abnormality observed was similar to that previously reported.
J Turbott; J Villiger; L Hunter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australian and New Zealand journal of psychiatry     Volume:  21     ISSN:  0004-8674     ISO Abbreviation:  Aust N Z J Psychiatry     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1988-03-02     Completed Date:  1988-03-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0111052     Medline TA:  Aust N Z J Psychiatry     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  327-38     Citation Subset:  IM    
Department of Psychiatry and Behavioural Science, School of Medicine, University of Auckland, New Zealand.
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MeSH Terms
Delayed-Action Preparations
Dose-Response Relationship, Drug
Flupenthixol / analogs & derivatives,  analysis,  pharmacokinetics,  therapeutic use*
Fluphenazine / analogs & derivatives*,  analysis,  pharmacokinetics,  therapeutic use
Heart / physiopathology
Middle Aged
Prolactin / blood*
Radioligand Assay
Schizophrenia / blood,  drug therapy*,  physiopathology
Thioxanthenes / therapeutic use*
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Thioxanthenes; 2709-56-0/Flupenthixol; 30909-51-4/flupenthixol decanoate; 5002-47-1/fluphenazine depot; 69-23-8/Fluphenazine; 9002-62-4/Prolactin

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