| Depot medroxyprogesterone acetate and bone mineral density in adolescents--the Black Box Warning: a Position Paper of the Society for Adolescent Medicine. | |
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MedLine Citation:
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PMID: 16857545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this Position Paper is to review the published Black Box Warning regarding depot medroxyprogesterone acetate (DMPA) and bone loss as it relates to adolescent girls. The scientific findings that prompted the Food and Drug Administration to issue the warning are reviewed and the following additional issues are considered: (1) likely low risk of fracture related to DMPA use, (2) evidence of at least partial recovery after discontinuation of the method, and (3) the need to balance the physical, social and economic cost of adolescent pregnancy versus the immediate and long-term impact of DMPA on bone. A list of clinical guidelines is included, the main recommendation of which is to continue prescription of DMPA, with counseling about the risks and benefits, in most of the adolescent population desiring to use this contraceptive method. |
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Authors:
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Barbara A Cromer; Delia Scholes; Abbey Berenson; Tim Cundy; M Kathleen Clark; Andrew M Kaunitz; |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of adolescent health : official publication of the Society for Adolescent Medicine Volume: 39 ISSN: 1879-1972 ISO Abbreviation: J Adolesc Health Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-21 Completed Date: 2006-08-24 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9102136 Medline TA: J Adolesc Health Country: United States |
Other Details:
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Languages: eng Pagination: 296-301 Citation Subset: IM |
Affiliation:
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CASE School of Medicine, Cleveland, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adolescent Medicine* Bone Density / drug effects* Bone Resorption / chemically induced Calcium, Dietary Contraceptive Agents, Female / administration & dosage, adverse effects*, contraindications Counseling Delayed-Action Preparations Drug Labeling Female Fractures, Bone / etiology Humans Medroxyprogesterone Acetate / administration & dosage, adverse effects*, contraindications Societies, Medical United States United States Food and Drug Administration |
| Chemical | |
Reg. No./Substance:
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0/Calcium, Dietary; 0/Contraceptive Agents, Female; 0/Delayed-Action Preparations; 71-58-9/Medroxyprogesterone Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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