Document Detail

Deposition and clearance of inhaled aerosol in the respiratory tract of chickens.
MedLine Citation:
PMID:  7153139     Owner:  NLM     Status:  MEDLINE    
Sixteen unanesthetized adult White Leghorn chickens (Gallus domesticus) were exposed to an aerosol of 99mTc-labeled submicrometric particles and killed 0, 1, 12, or 36 h later. The amount and distribution of radioactive particles retained in the lungs and skeletal system were measured to describe regional deposition and clearance. Particles were present in the lungs, air sacs, and skeletal system immediately after exposure. Reduction in activity with time suggested clearance of aerosol from the lungs and pneumatized bones. Aerosol particles were not distributed uniformly within the lungs; there was greater retention in the caudal regions. No dorsoventral gradients were observed. Of the initial lung deposition, 54 +/- 13.9% (SD) remained 1 h postexposure and 35.6 +/- 20.9% remained 36 h later. These data suggest an early fast phase of lung clearance followed by a slower phase. Detailed morphological studies are needed to understand the underlying clearance mechanisms and the bases for the differences in regional deposition.
G A Mensah; J D Brain
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  53     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1423-8     Citation Subset:  IM    
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MeSH Terms
Aerosols* / analysis
Bone and Bones / analysis
Chickens / physiology*
Digestive System / analysis
Lung / analysis
Respiratory Physiological Phenomena*
Technetium Tc 99m Sulfur Colloid
Grant Support
Reg. No./Substance:
0/Aerosols; 0/Technetium Tc 99m Sulfur Colloid; 7440-26-8/Technetium; 7704-34-9/Sulfur

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