Document Detail


Deposition and clearance of inhaled 18FDG powder in patients with chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  9657577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As freon is limited in its use as a generator for aerosol inhalation, powder particles are used as an alternative for inhalation therapy. The pulmonary deposition and clearance of inhaled powder particles was studied by positron emission tomography (PET) in ten patients with chronic obstructive pulmonary disease (COPD) and in five normal controls. The powder, 5 microm in mean diameter, was water soluble and labelled with 2-deoxy-2-[18F]-fluoro-D-glucose (18FDG). Powder inhalation was done with single deep inspiration from residual volume to total lung capacity. The initial deposition ratio in the right or left lung field to total inhaled dose, measured by an anteroposterior rectilinear scan, did not differ between normals and COPD patients. Ratios of radioactivity detected within the central and peripheral regions (the central to peripheral ratio) measured by the PET scan was not significantly different between COPD patients (4.8+/-2.6, mean+/-SD) and normals (2.6+/-0.8, mean+/-SD). However, the regional powder deposition in peripheral lung fields measured by the PET scan was significantly more uneven in COPD patients than in normal patients. The clearance rate of 18FDG, defined as the retention ratio of 18FDG activity to the initially deposited 18FDG at 60 and 120 min after inhalation, in the trachea, large bronchi or peripheral lung fields measured by tomographic scan showed a wider variation in COPD patients than in normals. To conclude, inhaled powder tended to be deposited more centrally and was distributed more unevenly in the peripheral lung in chronic obstructive pulmonary disease patients than in normals. This could be a limitation of powder inhalation used for therapy in chronic obstructive pulmonary disease patients.
Authors:
M Yanai; J Hatazawa; F Ojima; H Sasaki; M Itoh; T Ido
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  11     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-18     Completed Date:  1998-09-18     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1342-8     Citation Subset:  IM    
Affiliation:
Dept of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Aged
Bronchi / radionuclide imaging
Female
Fluorodeoxyglucose F18 / administration & dosage,  diagnostic use*
Humans
Lung / radionuclide imaging*
Lung Diseases, Obstructive / radionuclide imaging*,  therapy
Male
Middle Aged
Powders / administration & dosage*
Radiopharmaceuticals / administration & dosage,  diagnostic use*
Tomography, Emission-Computed*
Trachea / radionuclide imaging
Chemical
Reg. No./Substance:
0/Powders; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

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