Document Detail


Deposition of albuterol aerosol generated by pneumatic nebulizer in the Sophia Anatomical Infant Nose-Throat (SAINT) model.
MedLine Citation:
PMID:  20496045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To quantify distribution of albuterol aerosol generated by a pneumatic nebulizer within the nose and lungs of a model of a 9-month-old child (SAINT) and aerosol loss to the environment, during simulated breathing at increasing tidal volumes (TVs). METHODS: (99m)technetium-labeled albuterol aerosol was generated by an IPI nebulizer with face-mask. Deposition was quantified as a percentage of emitted dose using gamma scintigraphy. RESULTS: Lung deposition was similar for all TVs, averaging 7.17 +/- 0.01%, 9.34 +/- 0.01% and 9.41 +/- 0.02% at 50, 100 and 200 mL TV, respectively. In contrast, nose deposition increased significantly with TV, averaging 4.40 +/- 0.02%, 11.39 +/- 0.02% and 22.12 +/- 0.02% at 50 mL, 100 mL and 200 mL TV, respectively (all p < 0.0167). Aerosol loss to the environment was significantly lower at 200 mL TV (53.81 +/- 0.04%), compared to 50 mL (71.99 +/- 0.02%) (p < 0.0167). CONCLUSIONS: Our results suggest that nasal deposition of albuterol aerosol generated by a pneumatic nebulizer in 9-month-old infants may be significantly affected by changes in TV, ranging between 50 to 200 mL, whereas total lung deposition may not be affected. These results also predict that environmental losses would be highest when administering to a child breathing at 50 mL TV. These data should be useful to companies who are working to improve aerosol delivery systems to treat infants.
Authors:
Beth L Laube; Gail Sharpless; Charles Shermer; Omer Nasir; Vincent Sullivan; Kenneth Powell
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Publication Detail:
Type:  Journal Article     Date:  2010-05-22
Journal Detail:
Title:  Pharmaceutical research     Volume:  27     ISSN:  1573-904X     ISO Abbreviation:  Pharm. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1722-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA. blaube@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Aerosols / administration & dosage*,  analysis
Albuterol / administration & dosage*,  analysis*
Bronchodilator Agents / administration & dosage*,  analysis*
Humans
Infant
Models, Anatomic*
Nebulizers and Vaporizers / standards*
Organ Size
Particle Size
Tidal Volume
Chemical
Reg. No./Substance:
0/Aerosols; 0/Bronchodilator Agents; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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