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Deportation of trophoblastic emboli to maternal lung: A source of cell-free DNA in maternal blood?
MedLine Citation:
PMID:  21327145     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
During human pregnancy there is a continuous transport of numerous syncytiotrophoblastic cells from the intervillous space of the placenta into the maternal lung. There these cells undergo apoptosis and the fetal nuclear DNA is liberated within the pulmonary capillaries to become cffDNA in the maternal serum. We have examined the sections of lungs of 11 pregnant women (from 8 weeks to term gestation) who had come to the Medical Examiner's Offices after their traumatic demise. We then identified the deported, embolized trophoblastic cells in pulmonary capillaries and attempted to show them to contain hCG immunohistochemically but were unable to do this. We also determined their apoptotic profiles by TUNEL reaction.
Authors:
Kurt Benirschke; Lawrence Willes
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Chimerism (Print)     Volume:  1     ISSN:  1938-1964     ISO Abbreviation:  -     Publication Date:  2010 7 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101540510     Medline TA:  Chimerism     Country:  -    
Other Details:
Languages:  ENG     Pagination:  15-18     Citation Subset:  -    
Affiliation:
Professor of Pathology and Reproductive Medicine; Resident in Pathology; UCSD; Department of Pathology; University of California Medical Center; San Diego, CA USA.
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