Document Detail

Depolarization of skeletal muscle cells in culture by a cardiotoxin-like basic polypeptide from the venom of the Taiwan cobra (naja naja atra).
MedLine Citation:
PMID:  3629619     Owner:  NLM     Status:  MEDLINE    
A cardiotoxin-like basic polypeptide from the venom of Naja naja atra is homologous to cardiotoxins from the same venom, but much less toxic. To determine if it acts like the cardiotoxins its depolarizing ability was measured. It was about 10 times less potent than the cardiotoxins. Five amino acids are conserved in the sequences studied, on the exposed second and third loops of the toxin backbone. They may be part of the toxins' interactive site.
A L Harvey; K Hayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  25     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-06     Completed Date:  1987-10-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  681-4     Citation Subset:  IM    
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MeSH Terms
Chick Embryo
Cobra Venoms / toxicity*
Muscles / cytology,  drug effects*
Neuromuscular Depolarizing Agents*
Peptides / isolation & purification,  toxicity*
Reg. No./Substance:
0/Cobra Venoms; 0/Neuromuscular Depolarizing Agents; 0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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