Document Detail


Depletion of myocardial adenosine triphosphate during prolonged untreated ventricular fibrillation: effect on defibrillation success.
MedLine Citation:
PMID:  1965346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied left ventricular endomyocardial adenosine triphosphate levels in 13 large mongrel dogs before and during ventricular fibrillation induced cardiac arrest to assess whether myocardial adenosine triphosphate content could predict successful cardiopulmonary resuscitation. Endomyocardial biopsies were performed during sinus rhythm (control), after 15 min of ventricular fibrillation or 10 min of ventricular fibrillation and 5 min of open chest cardiopulmonary resuscitation, after 20 min of ventricular fibrillation and 10 min of open chest cardiopulmonary resuscitation and after 40 min ventricular fibrillation and 15-20 min open chest cardiopulmonary resuscitation. Myocardial adenosine triphosphate was measured utilizing a bioluminescence method adapted for use with endomyocardial biopsies and normalized to protein content. Left ventricular endomyocardial adenosine triphosphate content fell significantly over time from a control level of 8.88 +/- 0.9 micrograms/mg protein to 5.73 +/- 0.5 micrograms/mg protein at 15 min of cardiac arrest, to 3.4 +/- 0.4 micrograms/mg protein after 30 min of cardiac arrest and to 1.98 +/- 0.3 micrograms/mg protein after 60 min of cardiac arrest (P less than 0.001). Adenosine triphosphate levels were significantly different between animals that received 10 min of ventricular fibrillation and successful open chest cardiopulmonary resuscitation and those that received 40 min of ventricular fibrillation and unsuccessful open chest cardiopulmonary resuscitation (4.35 +/- 0.48 vs. 2.11 +/- 0.43 micrograms/mg protein; P less than 0.025).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
K B Kern; H S Garewal; A B Sanders; W Janas; J Nelson; D Sloan; W A Tacker; G A Ewy
Related Documents :
20679426 - Survival after cardiac arrest and severe lactic acidosis (ph 6.61) due to haemorrhage.
8090306 - Double simultaneous hemodialysis during prolonged cardio-pulmonary resuscitation for hy...
12356106 - Sudden cardiac death of an adolescent during dieting.
20154606 - Infliximab attenuates early myocardial dysfunction after resuscitation in a swine cardi...
11834046 - Biologic glue-molded "bio-mini-paddle" electrode used for atrial and ventricular pacing...
15693776 - Freehand three-dimensional echocardiography with rotational scanning for measurements o...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Resuscitation     Volume:  20     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-06-04     Completed Date:  1991-06-04     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  221-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Tucson 85724.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism*
Animals
Dogs
Electric Countershock*
Heart Arrest / metabolism,  therapy
Myocardium / metabolism*
Resuscitation*
Time Factors
Ventricular Fibrillation / metabolism,  therapy*
Grant Support
ID/Acronym/Agency:
HL-29398/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A comparison of transcranial Doppler ultrasound (TCD) and radioactive microspheres in determining ce...
Next Document:  Hemodynamic effects of 1-[3,4-dihydroxyphenyl]-1,2-diaminoethane versus norepinephrine during ventri...