| Depletion of myocardial adenosine triphosphate during prolonged untreated ventricular fibrillation: effect on defibrillation success. | |
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MedLine Citation:
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PMID: 1965346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied left ventricular endomyocardial adenosine triphosphate levels in 13 large mongrel dogs before and during ventricular fibrillation induced cardiac arrest to assess whether myocardial adenosine triphosphate content could predict successful cardiopulmonary resuscitation. Endomyocardial biopsies were performed during sinus rhythm (control), after 15 min of ventricular fibrillation or 10 min of ventricular fibrillation and 5 min of open chest cardiopulmonary resuscitation, after 20 min of ventricular fibrillation and 10 min of open chest cardiopulmonary resuscitation and after 40 min ventricular fibrillation and 15-20 min open chest cardiopulmonary resuscitation. Myocardial adenosine triphosphate was measured utilizing a bioluminescence method adapted for use with endomyocardial biopsies and normalized to protein content. Left ventricular endomyocardial adenosine triphosphate content fell significantly over time from a control level of 8.88 +/- 0.9 micrograms/mg protein to 5.73 +/- 0.5 micrograms/mg protein at 15 min of cardiac arrest, to 3.4 +/- 0.4 micrograms/mg protein after 30 min of cardiac arrest and to 1.98 +/- 0.3 micrograms/mg protein after 60 min of cardiac arrest (P less than 0.001). Adenosine triphosphate levels were significantly different between animals that received 10 min of ventricular fibrillation and successful open chest cardiopulmonary resuscitation and those that received 40 min of ventricular fibrillation and unsuccessful open chest cardiopulmonary resuscitation (4.35 +/- 0.48 vs. 2.11 +/- 0.43 micrograms/mg protein; P less than 0.025).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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K B Kern; H S Garewal; A B Sanders; W Janas; J Nelson; D Sloan; W A Tacker; G A Ewy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Resuscitation Volume: 20 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-06-04 Completed Date: 1991-06-04 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: IRELAND |
Other Details:
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Languages: eng Pagination: 221-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Tucson 85724. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism* Animals Dogs Electric Countershock* Heart Arrest / metabolism, therapy Myocardium / metabolism* Resuscitation* Time Factors Ventricular Fibrillation / metabolism, therapy* |
| Grant Support | |
ID/Acronym/Agency:
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HL-29398/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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