| Depletion of Ly6G/C(+) cells ameliorates delayed cerebral vasospasm in subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 21059474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The etiology of delayed cerebral vasospasm (DCV) after aneurysmal subarachnoid hemorrhage (SAH) has remained elusive. Growing evidence supports a role for inflammation in the pathogenesis of DCV. We showed that CSF neutrophils predict which patients will develop DCV. METHODS: We evaluated a murine model of SAH to test the hypothesis that myeloid cells are required for the cerebral damage associated with DCV. RESULTS: SAH was associated with decreased middle cerebral artery caliber on day 1 which normalized at day 3 and recurred at day 6. In addition, behavioral testing with a Barnes maze showed executive dysfunction that progressively worsened after the seventh day post hemorrhage. To test the role of innate immune responses, we administrated a myeloid cell-depleting monoclonal antibody against Ly6G/C prior to experimental SAH. Myeloid cell depletion ameliorated angiographic vasospasm measured by MCA vessel caliber and normalized behavioral testing. CONCLUSION: Our findings support the role of Ly6G/C(+) cells in the development of DCV after SAH and suggest that immune modulation of neutrophils or other Ly6G/C(+) cells may be a strategy for the prevention of DCV. |
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Authors:
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J Javier Provencio; Tamer Altay; Saksith Smithason; Shari Korday Moore; Richard M Ransohoff |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-11-06 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 232 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-09 Completed Date: 2011-05-17 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 94-100 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Neuroinflammation Research Center, Lerner Research Institute, NB3, Cleveland Clinic, 9500 Euclid Ave. Cleveland, OH 44195, United States. provenj@ccf.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Ly / immunology, metabolism Cell Separation Disease Models, Animal Flow Cytometry Immunohistochemistry Inflammation / complications*, immunology* Male Maze Learning Mice Mice, Inbred C57BL Middle Cerebral Artery / immunology, pathology Myeloid Cells / immunology, metabolism Neutrophils / immunology*, metabolism Subarachnoid Hemorrhage / complications*, immunology*, pathology Vasospasm, Intracranial / immunology*, pathology |
| Grant Support | |
ID/Acronym/Agency:
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K08 NS051350/NS/NINDS NIH HHS; K08 NS051350-04/NS/NINDS NIH HHS; K24 NS51400/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Ly; 0/Ly-6C antigen, mouse; 0/Ly6G antigen, mouse |
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