Document Detail

Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities.
MedLine Citation:
PMID:  22579419     Owner:  NLM     Status:  Publisher    
We synthesized benzoate ester derivatives of kojic acid with and without adamantane moiety. Benzoate derivatives 2a-e that did not contain an adamantane moiety showed potent tyrosinase inhibitory activities. However, depigmenting activity was not noted in a cell-based assay. Contrasting results were obtained for benzoate derivatives (3a-e) containing an adamantane moiety. Compounds 3a-e showed potent depigmenting activities without tyrosinase inhibitory activities. To the best of our knowledge, this is the first study showing the depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities.
Jun-Cheol Cho; Ho Sik Rho; Yung Hyup Joo; Chang Seok Lee; Jaekyoung Lee; Soo Mi Ahn; Jung Eun Kim; Song Seok Shin; Young-Ho Park; Kyung-Do Suh; Soo Nam Park
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-16
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-5-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Division of Chemical Engineering, College of Engineering, Hanyang University, Seoul 133-791, Republic of Korea.
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