Document Detail

Depigmenting effect of Kojic acid esters in hyperpigmented B16F1 melanoma cells.
MedLine Citation:
PMID:  23091364     Owner:  NLM     Status:  MEDLINE    
The depigmenting effect of kojic acid esters synthesized by the esterification of kojic acid using Rhizomucor miehei immobilized lipase was investigated in B16F1 melanoma cells. The depigmenting effect of kojic acid and kojic acid esters was evaluated by the inhibitory effect of melanin formation and tyrosinase activity on alpha-stimulating hormone- (α-MSH-) induced melanin synthesis in B16F1 melanoma cells. The cellular tyrosinase inhibitory effect of kojic acid monooleate, kojic acid monolaurate, and kojic acid monopalmitate was found similar to kojic acid at nontoxic doses ranging from 1.95 to 62.5 μg/mL. However, kojic acid monopalmitate gave slightly higher inhibition to melanin formation compared to other inhibitors at doses ranging from 15.63 to 62.5 μg/mL. Kojic acid and kojic acid esters also show antioxidant activity that will enhance the depigmenting effect. The cytotoxicity of kojic acid esters in B16F1 melanoma cells was significantly lower than kojic acid at high doses, ranging from 125 and 500 μg/mL. Since kojic acid esters have lower cytotoxic effect than kojic acid, it is suggested that kojic acid esters can be used as alternatives for a safe skin whitening agent and potential depigmenting agents to treat hyperpigmentation.
Ahmad Firdaus B Lajis; Muhajir Hamid; Arbakariya B Ariff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-02
Journal Detail:
Title:  Journal of biomedicine & biotechnology     Volume:  2012     ISSN:  1110-7251     ISO Abbreviation:  J. Biomed. Biotechnol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-23     Completed Date:  2013-01-16     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101135740     Medline TA:  J Biomed Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  952452     Citation Subset:  IM    
Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia.
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MeSH Terms
Cell Line, Tumor
Dose-Response Relationship, Drug
Esters / administration & dosage
Melanins / biosynthesis*
Melanoma, Experimental / metabolism*
Pyrones / administration & dosage*
Skin Lightening Preparations / pharmacology*
Reg. No./Substance:
0/Esters; 0/Melanins; 0/Pyrones; 0/Skin Lightening Preparations; 6K23F1TT52/kojic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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