Document Detail

Depigmentation patterns of nonsegmental vitiligo : a prospective study of macromorphologic changes in lesions.
MedLine Citation:
PMID:  23329080     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Efforts have been recently made to investigate simple, objective, accurate, and reproducible methods of clinical/noninvasive assessment of nonsegmental vitiligo. However, studies have mostly considered quantitative or semiquantitative parameters, almost neglecting the purely qualitative appearance of vitiligo lesions at a given moment and over time.
OBJECTIVE: The objective of this study was to investigate the dynamics of macromorphologic alterations taking place within vitiligo patches.
STUDY DESIGN: This was a prospective study of a vitiligo cohort.
PATIENT POPULATION: Consecutive patients affected by nonsegmental vitiligo.
METHODS: Enrolled patients affected by nonsegmental vitiligo underwent a dermatology visit once monthly for 12 months. Vitiligo lesions were photographed at each visit under both room light and Wood's light, and analyzed via a morphometric, digitalized software capable of detecting quantitative changes of white areas. Pictures depicting changing patches were evaluated in order to assess clinical morphology.
RESULTS: Ninety patients were included for the final analysis and 360 lesions were evaluated, 102 of which (28.9 %) showed changes of white areas. Subjective evaluation highlighted two distinct depigmentation patterns, which were present either alone or in combination: (1) a sharply defined band of intermediate color between the depigmented center and the surrounding normal skin, which was defined as 'marginal hypopigmentation;' and (2) pinpoint hypopigmented/depigmented macules centered by a follicle, which we named 'perifollicular depigmentation.' On the other hand, only one repigmentation pattern was detected, the already known 'perifollicular repigmentation.'
CONCLUSION: The depigmentation process in vitiligo seems to follow only two specific patterns. This preliminary study represents, in our opinion, a valuable background for future research aiming to investigate the dynamics of vitiligo pathogenesis or assess depigmentation/repigmentation patterns for monitoring treatment response.
Giovanni Menchini; Claudio Comacchi; Pietro Cappugi; Daniele Torchia
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical dermatology     Volume:  14     ISSN:  1175-0561     ISO Abbreviation:  Am J Clin Dermatol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100895290     Medline TA:  Am J Clin Dermatol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  55-9     Citation Subset:  IM    
Italian Group for the Study and Treatment of Vitiligo (GISV), Pisa, Italy.
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