| Dephosphorylation shows SR proteins the way out. | |
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MedLine Citation:
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PMID: 16307914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To address the role of the RS domain in shuttling and how it is differentially required for constitutive and alternative splicing, Lin et al. (2005 [in the November 11 issue of Molecular Cell]) employ an elegant somatic complementation system to reveal a novel phosphorylation-dependent mechanism regulating distinct recycling pathways for SR proteins during mRNP maturation. |
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Authors:
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Scott A Tenenbaum; Julio Aguirre-Ghiso |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: Molecular cell Volume: 20 ISSN: 1097-2765 ISO Abbreviation: Mol. Cell Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-25 Completed Date: 2006-01-05 Revised Date: 2011-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9802571 Medline TA: Mol Cell Country: United States |
Other Details:
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Languages: eng Pagination: 499-501 Citation Subset: IM |
Affiliation:
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Molecular Genetics, Department of Biomedical Sciences, School of Public Health, Ge*NY*Sis Center for Excellence in Cancer Genomics, 1 Discovery Drive, Room 220, Rensselaer, New York 12144, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Nuclear Proteins / chemistry, genetics, metabolism* Phosphoproteins / chemistry, genetics, metabolism* Phosphorylation Protein Transport / genetics RNA-Binding Proteins Ribonucleoproteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA109182-01A1/CA/NCI NIH HHS; R01 CA109182-02/CA/NCI NIH HHS; R01 CA109182-03/CA/NCI NIH HHS; R01 CA109182-04/CA/NCI NIH HHS; R01 CA109182-09/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nuclear Proteins; 0/Phosphoproteins; 0/RNA-Binding Proteins; 0/Ribonucleoproteins; 0/messenger ribonucleoprotein; 170974-22-8/serine-arginine-rich splicing proteins |
| Comments/Corrections | |
Comment On:
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Mol Cell. 2005 Nov 11;20(3):413-25
[PMID:
16285923
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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