| Dephosphorylation of circulating human osteopontin correlates with severe valvular calcification in patients with calcific aortic valve disease. | |
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MedLine Citation:
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PMID: 22191734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Calcific Aortic Valve Disease (CAVD) is an active pathological process leading to biomineralization of the aortic cusps. We characterized circulating and tissue Osteopontin (OPN) as a biomarker for CAVD. OBJECTIVES: Here we investigate the post-translational modifications of circulating OPN and correlate the phosphorylation status with the ability to prevent calcification. METHODS: Circulating OPN levels were estimated in CAVD patients (n = 51) and controls (n = 56). In a subgroup of 27 subjects, OPN was purified and the phosphorylation status analyzed. RESULTS: Plasma OPN levels were significantly elevated in CAVD patients as compared to the controls and correlates with the aortic valve calcium score. Our study demonstrates that phospho-threonine levels of OPN purified from controls were higher when compared to CAVD subjects, whereas phospho-serine and phospho-tyrosine levels were comparable between the two groups. CONCLUSION: The dephosphorylation of circulating OPN correlates with severe valvular calcification in patients with CAVD. |
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Authors:
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Rachana Sainger; Juan B Grau; Paolo Poggio; Emanuela Branchetti; Joseph E Bavaria; Joseph H Gorman; Robert C Gorman; Giovanni Ferrari |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-12-23 |
Journal Detail:
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Title: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Volume: 17 ISSN: 1366-5804 ISO Abbreviation: Biomarkers Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-01 Completed Date: 2012-07-23 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 9606000 Medline TA: Biomarkers Country: England |
Other Details:
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Languages: eng Pagination: 111-8 Citation Subset: IM |
Affiliation:
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Perelman School of Medicine at the University of Pennsylvania, Department of Surgery, Division of Cardiovascular Surgery, Philadelphia, PA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aortic Valve / metabolism*, pathology Aortic Valve Stenosis / blood, diagnosis*, pathology Biological Markers / blood* Calcinosis* Calcium / blood Case-Control Studies Female Humans Male Osteopontin / blood* Phosphorylation Phosphothreonine / blood Protein Processing, Post-Translational* Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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RC1 HL100035-02/HL/NHLBI NIH HHS; RC1HL100035/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 106441-73-0/Osteopontin; 1114-81-4/Phosphothreonine; 7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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