| Dependency between light intensity and refractive development under light-dark cycles. | |
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MedLine Citation:
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PMID: 21055401 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The emmetropization process involves fine-tuning the refractive state by altering the refractive components toward zero refraction. In this study, we provided light-dark cycle conditions at several intensities and examined the effect of light intensity on the progression of chicks' emmetropization. Chicks under high-, medium-, and low-light intensities (10,000, 500, and 50 lux, respectively) were followed for 90 days by retinoscopy, keratometry, as well as ultrasound measurements. Emmetropization was reached from days 30-50 and from days 50-60 for the low- and medium-intensity groups, respectively. On day 90, most chicks in the low-intensity group were myopic, with a mean refraction of -2.41D (95% confidence interval (CI) -2.9 to -1.8D), whereas no chicks in the high-intensity group developed myopia, but they exhibited a stable mean hyperopia of +1.1D. The medium-intensity group had a mean refraction of +0.03D. The low-intensity group had a deeper vitreous chamber depth and a longer axial length compared with the high-intensity group, and shifted refraction to the myopic side. The low-intensity group had a flatter corneal curvature, a deeper anterior chamber, and a thinner lens compared with the high-intensity group, and shifted refraction to the hyperopic side. In all groups the corneal power was correlated with the three examined levels of log light intensity for all examined times (e.g., day 20 r = 0.6 P < 0.0001, day 90 r = 0.56 P < 0.0001). Thus, under light-dark cycles, light intensity is an environmental factor that modulates the process of emmetropization, and the low intensity of ambient light is a risk factor for developing myopia. |
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Authors:
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Yuval Cohen; Michael Belkin; Oren Yehezkel; Arieh S Solomon; Uri Polat |
Publication Detail:
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Type: Journal Article Date: 2010-11-03 |
Journal Detail:
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Title: Experimental eye research Volume: 92 ISSN: 1096-0007 ISO Abbreviation: Exp. Eye Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370707 Medline TA: Exp Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 40-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Goldschleger Eye Research Institute, Tel Aviv University, 52621 Tel Hashomer, Israel. yuvalc@netvision.net.il |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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