| Dependence with nutritional status of the ethanol effects on fatty acid metabolism in rat hepatocytes. | |
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MedLine Citation:
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PMID: 3197909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The effects of ethanol on fatty acid synthesis, esterification and oxidation were studied in hepatocytes isolated from fed and 24 hr fasted rats. 2. [3H]H2O was preferentially incorporated into the glycerol backbone of triglycerides and phospholipids. Addition of ethanol markedly increased the incorporation of this label in both classes of glycerolipids; the increase was higher in fasted rat hepatocytes, both in the glycerol backbone and acyl groups of glycerolipids. 3. Ethanol increased [U-14C]palmitate incorporation into triglycerides only in hepatocytes from fasted rats. 4. [14C]CO2 and total acid soluble product formation from [1-14C]palmitate resulted inhibited by ethanol both in the fed and the fasted state. |
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Authors:
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A Maquedano; M Guzmán; J Castro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of biochemistry Volume: 20 ISSN: 0020-711X ISO Abbreviation: Int. J. Biochem. Publication Date: 1988 |
Date Detail:
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Created Date: 1989-01-26 Completed Date: 1989-01-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0250365 Medline TA: Int J Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 937-41 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica, Facultad de Química, Universidad Complutense, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ethanol / pharmacology* Fatty Acids / metabolism* Liver / drug effects*, metabolism Male Nutritional Status Palmitic Acid Palmitic Acids / metabolism Rats Rats, Inbred Strains Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Palmitic Acids; 0/Triglycerides; 57-10-3/Palmitic Acid; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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