Document Detail

Dependence of tonin activity in rat submaxillary gland on growth hormone and testosterone.
MedLine Citation:
PMID:  193408     Owner:  NLM     Status:  MEDLINE    
Tonin, an enzyme present in rat submaxillary gland, converts angiotensin I to angiotensin II and is able to form angiotensin II directly from renin substrates. This enzyme was previously shown to be different from renin, tissue isorenins, and angiotensin I converting enzyme. The specific activity of tonin in rat submaxillary gland increases with the age of the animal and is much higher in male than in female rats; this sex difference is apparent from 60 to 70 days of age. There is a sharp drop of tonin activity in hypophysectomized animals, whereas adrenalectomy, thyroidectomy, and gonadectomy have have little effect. The marked increase in tonin activity was observed in animals bearing MtT-F4 transplantable tumors known to produce ACTH, prolactin, and growth hormone. Tonin specific activity in hypophysectomized male rats is restored to control levels by combined treatment with growth hormone and testosterone. Prolactin alone or in combination with testosterone, as well as transplanted pituitaries, has no effect in hypophysectomized animals. There is a significant specific binding of 125I-labeled growth hormone to isolated membranes of rat submaxillary gland.
M Lis; R Boucher; M Chrétien; J Genest
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  232     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E522-5     Citation Subset:  IM    
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MeSH Terms
Age Factors
Angiotensin II
Binding Sites
Growth Hormone / metabolism,  pharmacology*
Peptidyl-Dipeptidase A / metabolism*
Prolactin / metabolism
Sex Factors
Submandibular Gland / enzymology*,  metabolism
Testosterone / pharmacology*
Reg. No./Substance:
11128-99-7/Angiotensin II; 58-22-0/Testosterone; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone; EC A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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