| Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design. | |
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MedLine Citation:
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PMID: 15808468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel pyridine diamine-based cyclic enediyne 1 was synthesized by bis-N-alkylation of 2,6-bis-sulfonamido pyridine 6 followed by deprotection with thiophenol. A variety of salts 1a-c of the parent amine 1 were prepared. Thermal reactivity studies indicated a dependence of the reactivity upon the extent of salt formation. This observation may be useful in pH-based design of enediynes. |
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Authors:
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Amit Basak; Moumita Kar; Subrata Mandal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 15 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-05 Completed Date: 2005-08-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 2061-4 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India. absk@chem.iitkgp.ernet.in <absk@chem.iitkgp.ernet.in> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acids Drug Design* Enediynes Hydrogen-Ion Concentration Pyridines / analysis, chemistry* Pyrimidines / analysis, chemistry* Salts / analysis, chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Acids; 0/Enediynes; 0/Pyridines; 0/Pyrimidines; 0/Salts; 0/enediynone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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