Document Detail

Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design.
MedLine Citation:
PMID:  15808468     Owner:  NLM     Status:  MEDLINE    
A novel pyridine diamine-based cyclic enediyne 1 was synthesized by bis-N-alkylation of 2,6-bis-sulfonamido pyridine 6 followed by deprotection with thiophenol. A variety of salts 1a-c of the parent amine 1 were prepared. Thermal reactivity studies indicated a dependence of the reactivity upon the extent of salt formation. This observation may be useful in pH-based design of enediynes.
Amit Basak; Moumita Kar; Subrata Mandal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  15     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-05     Completed Date:  2005-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  2061-4     Citation Subset:  IM    
Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India. <>
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MeSH Terms
Drug Design*
Hydrogen-Ion Concentration
Pyridines / analysis,  chemistry*
Pyrimidines / analysis,  chemistry*
Salts / analysis,  chemistry*
Reg. No./Substance:
0/Acids; 0/Enediynes; 0/Pyridines; 0/Pyrimidines; 0/Salts; 0/enediynone

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