| Dependence of peak oxygen uptake on oxygen transport capacity in chronic heart failure: comparison of graded protocol and fixed protocol. | |
| | |
MedLine Citation:
|
PMID: 9158167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Oxygen transport capacity is the most important determinant of maximum oxygen uptake (V(O2) max) in healthy subjects, however, its role is controversial in patients with chronic heart failure (CHF). The aim of this study was to clarify whether the oxygen transport capacity is an actual determinant of exercise capacity in CHF patients. Thirteen CHF patients underwent two maximum exercise tests, i.e., a graded protocol test and a fixed protocol test, measuring expiratory gases, leg blood flow (LBF), and arterial and venous blood gases. The workload of the fixed protocol was set to exceed the peak workload obtained by the graded protocol. Exercise with the fixed protocol caused significantly larger peak V(O2) compared to the graded protocol (813+/-194 to 971+/-203 ml/min, P<0.001). Peak LBF increased by 17%, while the peak leg arterio-venous oxygen difference increased by 5% from the graded protocol to the fixed protocol. The linear correlation between leg venous partial oxygen pressure and peak V(O2) was more clearly manifested in the fixed protocol (r=0.60, P<0.05) than in the graded protocol (r=0.47, NS). In conclusion, the exercise with graded protocol did not always conduct the upper limit of oxygen demand/supply relationship in CHF patients, whereas, the fixed protocol with a larger workload produced larger peak V(O2) and manifested the mechanism to limit V(O2) by oxygen transport capacity. |
| | |
Authors:
|
Y Yasaka; H Yamabe; M Yokoyama |
Related Documents
:
|
20227917 - Exercise & sports science australia position statement on exercise training and chronic... 7572657 - Lung-heart interaction as a substrate for the improvement in exercise capacity after bo... 12695297 - Enhanced ventilatory response to exercise in patients with chronic heart failure and ce... 10997747 - Functional capacity in patients with congestive heart failure. 9493647 - The birth and development of the forced expiratory manoeuvre: a tribute to robert tiffe... 12486057 - Requirement of arca for redox regulation in escherichia coli under microaerobic but not... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: International journal of cardiology Volume: 59 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1997 Apr |
Date Detail:
|
Created Date: 1997-06-10 Completed Date: 1997-06-10 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 149-56 Citation Subset: IM |
Affiliation:
|
The First Department of Internal Medicine, Kobe University School of Medicine, Chuo-ku, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Arteries Blood Pressure Capillaries / physiopathology Carbon Dioxide / analysis, blood Exercise Test / methods Exercise Tolerance* Heart Failure / metabolism, physiopathology* Heart Rate / physiology Hemoglobins / metabolism Humans Leg / blood supply Linear Models Middle Aged Oxygen / analysis, blood* Oxygen Consumption / physiology* Partial Pressure Pulmonary Wedge Pressure / physiology Regional Blood Flow Stroke Volume / physiology Veins |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationship between isokinetic muscle strength and exercise capacity in chronic heart failure.
Next Document: Cardiac arrhythmias as presenting symptoms in patients with limb-girdle muscular dystrophy.