| Dependence of paranodal junctional gap width on transverse bands. | |
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MedLine Citation:
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PMID: 22434587 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mouse mutants with paranodal junctional (PNJ) defects display variable degrees of neurological impairment. In this study we compare control paranodes with those from three mouse mutants that differ with respect to a conspicuous PNJ component, the transverse bands (TBs). We hypothesize that TBs link the apposed junctional membranes together at a fixed distance and thereby determine the width of the junctional gap, which may in turn determine the extent to which nodal action currents can be short-circuited underneath the myelin sheath. Electron micrographs of aldehyde-fixed control PNJs, in which TBs are abundant, show a consistent junctional gap of ˜ 3.5 nm. In Caspr-null PNJs, which lack TBs entirely, the gap is wider (˜ 6-7 nm) and more variable. In CST-null PNJs, which have only occasional transverse bands, the mean PNJ gap width is comparable to that in Caspr-null mice. In the shaking mutant, in contrast, which has approximately 60% of the normal complement of transverse bands, mean PNJ gap width is not significantly different from than that in controls. Correspondingly, shaking mice are much less impaired neurologically than either Caspr-null or CST-null mice. We conclude that in the absence or gross diminution of TBs, mean PNJ gap width increases significantly and suggest that this difference could underlie some of the neurological impairment seen in those mutants. Surprisingly, even in the absence of TBs, paranodes are to some extent maintained in their usual form, implying that in addition to TBs, other factors govern the formation and maintenance of overall paranodal structure. J. Comp. Neurol., 2012. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Jack Rosenbluth; Chris Petzold; Elior Peles |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-20 |
Journal Detail:
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Title: The Journal of comparative neurology Volume: - ISSN: 1096-9861 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0406041 Medline TA: J Comp Neurol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Dept. Physiology & Neuroscience, NYU School of Medicine. rosenj03@med.nyu.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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