Document Detail

Dependence of pK(a) on solute cavity for diprotic and triprotic acids.
MedLine Citation:
PMID:  21528149     Owner:  NLM     Status:  Publisher    
A systematic study of ΔG(aq)/pK(a) for monoprotic, diprotic, and triprotic acids has been carried out based on DFT/aug-cc-pVTZ combined with CPCM and SMD solvation modeling. All DFT/cavity set combinations considered showed similar accuracy for ΔG(aq)(1)/pK(a1) (70% within ±2.5 kcal mol(-1) of experiment) while only the M05-2X/Pauling cavity combination gave reasonable results for ΔG(aq)(2)/pK(a2) when both pK(a) values are separated by more than three units (70% within ±5.0 kcal mol(-1) of experiment). The choice of experimental data is critical to the interpretation of the calculated accuracy especially for several inorganic acids. For the calculation of ΔG(aq)(3)/pK(a3), the larger experimental uncertainty and an unrealistic orbital population of diffuse function for trianions in the gas phase hinders an evaluation of the predictive performance. We find the M05-2X functional with the Pauling cavity set is the best choice for ΔG(aq)(2)/pK(a2) prediction in aqueous media while all DFT/cavity sets considered were competitive for ΔG(aq)(1)/pK(a1).
Tae Bum Lee; Michael L McKee
Related Documents :
20968839 - Negative velocity dispersion and attenuation in granular marine sediments.
704669 - A comparison of optimum detector spatial resolution in nuclear imaging based on statist...
25253999 - Incorporating spatial variability within epidemiological studies of environmental expos...
11370369 - Experimental validation for the diffraction effect in the ultrasonic field of piston tr...
22874329 - Assessment in health care education - modelling and implementation of a computer suppor...
23381499 - On the optimal size of marine reserves.
20655049 - Validation of the delft shoulder and elbow model using in-vivo glenohumeral joint conta...
22228149 - Physiologically based pharmacokinetic (pbpk) modelling tools: how to fit with our needs?
20089719 - Variability of renal apparent diffusion coefficients: limitations of the monoexponentia...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-28
Journal Detail:
Title:  Physical chemistry chemical physics : PCCP     Volume:  -     ISSN:  1463-9084     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888160     Medline TA:  Phys Chem Chem Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surface chemical modifications and surface reactivity of nanodiamonds hydrogenated by CVD plasma.
Next Document:  Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of ...