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Dependence of the optic nerve sheath diameter on acutely applied subarachnoidal pressure - an experimental ultrasound study.
MedLine Citation:
PMID:  21518306     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Purpose:  To determine the distensibility and elastic characteristics of the optic nerve sheath for development of a basic understanding of ultrasound studies aimed to measure optic nerve sheath diameter (ONSD) for detection of acutely elevated intracranial pressure (ICP). Methods:  Isolated human optic nerves preparations obtained from autopsies were submitted to predefined pressure alterations, and consecutive changes in ONSD were measured by B-scan ultrasound under defined conditions. Results:  Following submission to pressure, the diameter of the nerve sheath increased up to 140% of its baseline value. The increase (mean 1.97 mm, SD 0.52 mm) corresponded to the magnitude of pressure steps measured in the perineural subarachnoidal space (SAS). Similarly, the ONSD declined in each of the preparations within a few minutes after the optic nerve was decompressed. However, it did not reach its baseline value again when pressure loads of 45-55 mmHg or more had been applied. Conclusions:  The elasticity of the anterior sheath of the optic nerve is sufficient for the detection of pressure changes in the SAS especially for upward pressure steps. This is basically important for the application of clinical monitoring of the sheath diameter to facilitate the identification of patients with elevated ICP non-invasively (screening). However, further implementation of this procedure in neurointensive care and emergency medicine has to consider that the sheath diameter reversibility may be impaired after episodes of prolonged intracranial hypertension and a model for hysteresis is proposed.
Authors:
Hans-Christian Hansen; Wolf Lagrèze; Oswald Krueger; Knut Helmke
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-21
Journal Detail:
Title:  Acta ophthalmologica     Volume:  -     ISSN:  1755-3768     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468102     Medline TA:  Acta Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Acta Ophthalmologica © 2011 Acta Ophthalmologica Scandinavica Foundation.
Affiliation:
Department of Neurology & Psychiatry, Friedrich-Ebert-Hospital Neumuenster (FEK)/University of Hamburg, Hamburg, Germany Department of Ophthalmology, University Hospital Freiburg, Freiburg, Germany Federal Institute for Materials Research and Testing (BAM) Unter den Eichen, Berlin, Germany Department of Pediatric Radiology, University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany.
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