| Dependence of lung injury on surface tension during low-volume ventilation in normal open-chest rabbits. | |
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MedLine Citation:
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PMID: 16959911 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the role of pulmonary surfactant in the prevention of lung injury caused by mechanical ventilation (MV) at low end-expiratory volumes, lung mechanics and morphometry were assessed in three groups of eight normal, open-chest rabbits ventilated for 3-4 h at zero end-expiratory pressure (ZEEP) with physiological tidal volumes (Vt = 10 ml/kg). One group was left untreated (group A); the other two received surfactant intratracheally (group B) or aerosolized dioctylsodiumsulfosuccinate (group C) before MV on ZEEP. Relative to initial MV on positive end-expiratory pressure (PEEP; 2.3 cmH(2)O), quasi-static elastance (Est) and airway (Rint) and viscoelastic resistance (Rvisc) increased on ZEEP in all groups. After restoration of PEEP, only Rint (124%) remained elevated in group A, only Est (36%) was significantly increased in group B, whereas in group C, Est, Rint, and Rvisc were all markedly augmented (274, 253, and 343%). In contrast, prolonged MV on PEEP had no effect on lung mechanics of eight open-chest rabbits (group D). Lung edema developed in group C (wet-to-dry ratio = 7.1), but not in the other groups. Relative to group D, both groups A and C, but not B, showed histological indexes of bronchiolar injury, whereas all groups exhibited an increased number of polymorphonuclear leukocytes in alveolar septa, which was significantly greater in group C. In conclusion, administration of exogenous surfactant largely prevents the histological and functional damage of prolonged MV at low lung volumes, whereas surfactant dysfunction worsens the functional alterations, also because of edema formation and, possibly, increased inflammatory response. |
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Authors:
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Edgardo D'Angelo; Matteo Pecchiari; Guendalina Gentile |
Publication Detail:
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Type: Journal Article Date: 2006-09-07 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 102 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-08 Completed Date: 2007-03-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 174-82 Citation Subset: IM |
Affiliation:
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Istituto di Fisiologia Umana I, Università di Milano, Milan, Italy. edgardo.dangelo@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dioctyl Sulfosuccinic Acid / pharmacology Elasticity Lung / pathology, physiopathology* Lung Injury* Lung Volume Measurements Mathematics Positive-Pressure Respiration Rabbits Respiration, Artificial / adverse effects* Respiratory Mechanics / drug effects, physiology* Surface Tension / drug effects Surface-Active Agents / pharmacology Tidal Volume / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Surface-Active Agents; 10041-19-7/Dioctyl Sulfosuccinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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