| Dependence of defibrillation threshold upon extracellular/intracellular K+ concentrations. | |
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MedLine Citation:
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PMID: 7359067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of increasing extracellular potassium concentration (Ko) upon electrical ventricular defibrillation threshold was investigated in pentobarbital anesthetized dogs treated with intravenous potassium chloride. Defibrillation threshold fell duirng potassium intoxication. The percent decrease in defibrillation threshold was linearly related to the logarithm of Ko and to the potassium equilibrium potential (Ek), calculated from measured extracellular and intracellular potassium concentrations of ventricular muscle. In dogs supported by left ventricular bypass in order to maintain the circulation during potassium intoxication, the values of Ko and Ek required for spontaneous, K+ induced defibrillation (electrical defibrillation threshold = zero) were 16.6 mEq/L and -46 mV compared to the normal values of 3.9 mEq/L and -84 mV. Changes in defibrillation threshold related to changes in Ek may be significant events in digitalis intoxication and in myocardial anoxia during prolonged fibrillation. |
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Authors:
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C F Babbs; S J Whistler; G K Yim; W A Tacker; L A Geddes |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of electrocardiology Volume: 13 ISSN: 0022-0736 ISO Abbreviation: J Electrocardiol Publication Date: 1980 |
Date Detail:
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Created Date: 1980-05-14 Completed Date: 1980-05-14 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 73-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / physiopathology Digitalis Glycosides / poisoning Dogs Electric Countershock* Extracellular Space / metabolism Heart / drug effects, physiopathology Intracellular Fluid / metabolism Membrane Potentials / drug effects Models, Biological* Myocardial Contraction* / drug effects Myocardium / metabolism* Potassium / metabolism*, physiology, poisoning Potassium Chloride / pharmacology Ventricular Fibrillation / metabolism, therapy |
| Chemical | |
Reg. No./Substance:
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0/Digitalis Glycosides; 7440-09-7/Potassium; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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