Document Detail

Dependence of changes in beta-adrenoceptor signal transduction on type and stage of cardiac hypertrophy.
MedLine Citation:
PMID:  17122376     Owner:  NLM     Status:  MEDLINE    
To examine whether cardiac hypertrophy is associated with changes in beta-adrenoceptor signal transduction mechanisms, pressure overload (PO) was induced by occlusion of the abdominal aorta and volume overload (VO) by creation of an aortocaval shunt for 4 and 24 wk in rats. After hemodynamic assessment of the animals, the left ventricular (LV) particulate fraction was isolated for measurement of beta(1)-adrenoceptors and adenylyl cyclase activity, and cardiomyocytes were isolated for monitoring of the intracellular Ca(2+) concentration. Although PO and VO produced cardiac hypertrophy and increased LV end-diastolic pressure at 4 wk, cardiac function was increased in animals subjected to PO but remained unaltered in animals subjected to VO. Cardiac hypertrophy and increased LV end-diastolic pressure were associated with depressed cardiac function at 24 wk of PO or VO, but clinical signs of congestive heart failure were evident only in animals subjected to VO. Isoproterenol-induced increases in cardiac function, activation of adenylyl cyclase activity, and increase in intracellular Ca(2+) concentration, as well as beta(1)-adrenoceptor density, were unaltered by PO at 4 wk, augmented by VO at 4 wk, and attenuated by PO and VO at 24 wk. These results suggest that alterations in beta(1)-adrenoceptor signal transduction are dependent on the type and stage of cardiac hypertrophy.
Rajat Sethi; Harjot K Saini; Xiaobing Guo; Xi Wang; Vijayan Elimban; Naranjan S Dhalla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-22
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  102     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-07     Completed Date:  2007-04-30     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  978-84     Citation Subset:  IM    
Department of Pharmaceutical Sciences, Texas A & M University Health Sciences Center, Kingsville, Texas, USA.
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MeSH Terms
Adenylate Cyclase / metabolism
Calcium / metabolism
Cardiomegaly / metabolism*,  physiopathology
Cardiotonic Agents / diagnostic use
Isoproterenol / diagnostic use
Myocytes, Cardiac / metabolism
Rats, Sprague-Dawley
Receptors, Adrenergic, beta / metabolism*
Signal Transduction / physiology*
Ventricular Function, Left / physiology
Reg. No./Substance:
0/Cardiotonic Agents; 0/Receptors, Adrenergic, beta; 7440-70-2/Calcium; 7683-59-2/Isoproterenol; EC Cyclase

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