| Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish. | |
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MedLine Citation:
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PMID: 21246662 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Maturation of the developing heart requires the structural elaboration of the embryonic ventricle through the process of trabeculation. Trabeculae form as the ventricular myocardium protrudes into the lumen of the chamber, thereby increasing muscle mass and altering functional output. Little is understood about the cellular basis for trabeculation and its genetic regulation. Here, we establish the utility of the zebrafish embryo for the analysis of the mechanisms driving trabeculation. In zebrafish, we can follow trabeculation in four dimensions and define morphologically discrete stages for the initiation, propagation, and network elaboration that form the ventricular trabeculae. We find that Neuregulin/ErbB signaling is required for the initial protrusion of the myocardium into the ventricular lumen. Additionally, we demonstrate that optimal blood flow through the ventricle is important for the advancement of trabeculation. Thus, our results indicate that the zebrafish provides a valuable model for investigating possible causes of congenital defects in trabeculation. Developmental Dynamics 240:446-456, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Courtney Peshkovsky; Ronald Totong; Deborah Yelon |
Publication Detail:
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Type: Journal Article Date: 2011-01-03 |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 240 ISSN: 1097-0177 ISO Abbreviation: Dev. Dyn. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 446-56 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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