Document Detail


Deoxynivalenol: toxicology and potential effects on humans.
MedLine Citation:
PMID:  15762554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereal-based foods worldwide. At the molecular level, DON disrupts normal cell function by inhibiting protein synthesis via binding to the ribosome and by activating critical cellular kinases involved in signal transduction related to proliferation, differentiation, and apoptosis. Relative to toxicity, there are marked species differences, with the pig being most sensitive to DON, followed by rodent > dog > cat > poultry > ruminants. The physiologic parameter that is most sensitive to low-level DON exposure is the emetic response, with as little as 0.05 to 0.1 mg/kg body weight (bw) inducing vomiting in swine and dogs. Chinese epidemiological studies suggest that DON may also produce emetic effects in humans. With respect to chronic effects, growth (anorexia and decreased nutritional efficiency), immune function, (enhancement and suppression), and reproduction (reduced litter size) are also adversely affected by DON in animals, whereas incidence of neoplasia is not affected. When hazard evaluations were conducted using existing chronic toxicity data and standard safety factors employed for anthropogenic additives/contaminants in foods, tolerable daily intakes (TDIs) ranging from 1 to 5 microg/kg bw have been generated. Given that critical data gaps still exist regarding the potential health effects of DON, additional research is needed to improve capacity for assessing adverse health effects of this mycotoxin. Critical areas for future DON research include molecular mechanisms underlying toxicity, sensitivity of human cells/tissues relative to other species, emetic effects in primates, epidemiological association with gastroenteritis and chronic disease in humans, and surveillance in cereal crops worldwide.
Authors:
James J Pestka; Alexa T Smolinski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part B, Critical reviews     Volume:  8     ISSN:  1093-7404     ISO Abbreviation:  J Toxicol Environ Health B Crit Rev     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-03-14     Completed Date:  2005-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9802627     Medline TA:  J Toxicol Environ Health B Crit Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-69     Citation Subset:  IM    
Affiliation:
Department of Food Science and Human Nutrition, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824-1224, USA. pestka@msu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cereals / microbiology*
Environmental Exposure
Environmental Monitoring
Food Microbiology*
Fusarium / metabolism*
Humans
Mycotoxins / toxicity*
Risk Assessment
Species Specificity
Trichothecenes / toxicity*
Grant Support
ID/Acronym/Agency:
ES-03358/ES/NIEHS NIH HHS; ES-09521/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Mycotoxins; 0/Trichothecenes; 51481-10-8/deoxynivalenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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