| Deoxycorticosterone and 17-ketosteroids. Elevated levels in adult hypertensive patients. | |
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MedLine Citation:
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PMID: 660829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma 11-deoxycorticosterone levels were manyfold elevated in three adult patients with hypertension and elevated urinary excretion levels of 17-ketosteroids but without Cushing's syndrome. Dexamethasone therapy resulted in suppression of these steroids and in improvement of blood pressure in two of the patients. A partial adrenal 11beta-hydroxylase deficiency appears to best explain these findings. |
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Authors:
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S Y Tan; R H Noth; P J Mulrow |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: JAMA : the journal of the American Medical Association Volume: 240 ISSN: 0098-7484 ISO Abbreviation: JAMA Publication Date: 1978 Jul |
Date Detail:
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Created Date: 1978-08-14 Completed Date: 1978-08-14 Revised Date: 2006-11-07 |
Medline Journal Info:
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Nlm Unique ID: 7501160 Medline TA: JAMA Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 123-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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17-Ketosteroids
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urine* Adrenal Glands / secretion Adult Age Factors Blood Pressure / drug effects Cushing Syndrome Desoxycorticosterone / blood* Dexamethasone / pharmacology, therapeutic use* Female Humans Hypertension / blood*, drug therapy, urine Male Mixed Function Oxygenases / deficiency |
| Chemical | |
Reg. No./Substance:
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0/17-Ketosteroids; 50-02-2/Dexamethasone; 64-85-7/Desoxycorticosterone; EC 1.-/Mixed Function Oxygenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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