Document Detail


Deoxycorticosterone and 17-ketosteroids. Elevated levels in adult hypertensive patients.
MedLine Citation:
PMID:  660829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma 11-deoxycorticosterone levels were manyfold elevated in three adult patients with hypertension and elevated urinary excretion levels of 17-ketosteroids but without Cushing's syndrome. Dexamethasone therapy resulted in suppression of these steroids and in improvement of blood pressure in two of the patients. A partial adrenal 11beta-hydroxylase deficiency appears to best explain these findings.
Authors:
S Y Tan; R H Noth; P J Mulrow
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  JAMA     Volume:  240     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
17-Ketosteroids / urine*
Adrenal Glands / secretion
Adult
Age Factors
Blood Pressure / drug effects
Cushing Syndrome
Desoxycorticosterone / blood*
Dexamethasone / pharmacology,  therapeutic use*
Female
Humans
Hypertension / blood*,  drug therapy,  urine
Male
Mixed Function Oxygenases / deficiency
Chemical
Reg. No./Substance:
0/17-Ketosteroids; 40GP35YQ49/Desoxycorticosterone; 7S5I7G3JQL/Dexamethasone; EC 1.-/Mixed Function Oxygenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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