Document Detail


Deoxycholate-treated, nontoxic, whole-cell vaccine protective against experimental salmonellosis of mice.
MedLine Citation:
PMID:  4901358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A vaccine prepared from the residue after extraction of whole cells of Salmonella typhimurium with 2% sodium deoxycholate proved to be nontoxic and highly immunogenic. The material was not lethal for mice at 6.0 mg and was essentially nontoxic in rabbit skin, whereas endotoxic activity was found in the dialyzed extract. A high dosage, above 2.0 mg, was less protective than lower doses, indicating a degree of "immunologic paralysis." Three inoculations of low doses, 0.25 mg each, induced protection against death and tissue infection in animals challenged with 2,000 ld(50) of virulent homologous S. typhimurium and against death, but not against tissue infection, after heterologous challenge with S. enteritidis. Residues of purified cell walls were as effective as residues of whole cells, indicating that the immunizing antigen(s) resided in the cell wall.
Authors:
F F Badakhsh; M Herzberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  100     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1969 Nov 
Date Detail:
Created Date:  1970-01-10     Completed Date:  1970-01-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  738-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Vaccines* / administration & dosage
Bile Acids and Salts / pharmacology*
Centrifugation
Culture Media
Endotoxins / toxicity
Injections, Intraperitoneal
Methods
Mice
Necrosis
Rabbits
Salmonella Infections, Animal / immunology*,  prevention & control
Salmonella typhimurium / immunology*
Chemical
Reg. No./Substance:
0/Bacterial Vaccines; 0/Bile Acids and Salts; 0/Culture Media; 0/Endotoxins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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