Document Detail

Deodorants: a clinical provocation study in fragrance-sensitive individuals.
MedLine Citation:
PMID:  9817220     Owner:  NLM     Status:  MEDLINE    
Deodorants are one of the most marketed types of cosmetics and are frequently reported as a cause of dermatitis, particularly among fragrance-sensitive persons. The aim of this study was to investigate the ability of deodorants, which had previously caused axillary dermatitis in fragrance-mix-sensitive eczema patients, to provoke reactions on repeated open application tests on the upper arm and in the axillae, and to relate the findings to the content of fragrance-mix constituents in those deodorants. 14 eczema patients performed a 7-day use test with 1 or 2 deodorants that had caused a rash within the last 12 months. 2 applications per day were made in the axilla and simultaneously on a 25 cm2 area on the upper arm. A total of 20 deodorants were tested among the 14 patients. Afterwards, the deodorants were subjected to quantitative chemical analysis identifying constituents of the fragrance mix. 12/20 (60%) deodorants elicited eczema on use testing in the axilla. 8/12 deodorants were positive in the axilla on day (D) 7 and 4 both in the axilla and on the upper arm. 2 of the 4 developed a reaction in the axilla before it developed on the upper arm. Chemical analysis revealed that 18/19 deodorants contained between 1 and 6 of the fragrance-mix constituents, on average 3 being found. The mean concentration of fragrance-mix constituents was generally higher in the deodorants causing a positive use test, as compared with those giving a negative reaction, indicating that the differences between the deodorants in terms of elicitation potential were more related to quantitative aspects of allergen content than of a qualitative nature. It is recommended that deodorants are tested in the axilla in the case of a negative use test on the upper arm and a strong clinical suspicion.
J D Johansen; S C Rastogi; M Bruze; K E Andersen; P Frosch; B Dreier; J P Lepoittevin; I White; T Menné
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contact dermatitis     Volume:  39     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-07     Completed Date:  1999-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Allergens / adverse effects
Deodorants / adverse effects,  analysis*,  chemistry
Dermatitis, Allergic Contact / etiology
Eczema / chemically induced
Patch Tests / methods
Perfume / adverse effects
Skin / drug effects,  pathology
Reg. No./Substance:
0/Allergens; 0/Deodorants; 0/Perfume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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