Document Detail


Dentomaxillofacial manifestations of Gaucher's disease: preliminary clinical and radiographic findings.
MedLine Citation:
PMID:  22988312     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: A wide variety of manifestations is presented in patients with Gaucher's disease (GD), including bone, haematology and visceral disturbances. This study was conducted to ascertain the main maxillofacial abnormalities by means of clinical survey, panoramic and cone beam CT (CBCT); to compare the patient's group with an age-sex matched control group; and to correlate clinical and radiological data.
METHODS: Ten patients previously diagnosed with GD were submitted to clinical and radiological surveys (CBCT and panoramic radiographs). The examination consisted of anamnesis, extra- and intraoral examinations and analyses of each patient's records. Imaging data were collected from the point of view of 3 observers, and the results compared with a healthy group (20 individuals) by means of statistical analysis (Fisher's exact test).
RESULTS: Gaucher patients had significantly more manifestations than otherwise healthy carriers. The most prevalent findings were enlarged marrow spaces, generalized osteopenia and effacement of jaw structures (mandibular canal, lamina dura and mental foramen). Here we describe a case in which thickening of the maxillary sinus mucosa was observed on CBCT rather than opacification of the sinus as seen on panoramic radiographs. Pathological fractures, root resorption and delay on tooth eruption were not observed.
CONCLUSIONS: A poor relationship could be observed between clinical and radiological data. Patients showed important bone manifestations, which require careful diagnostic and surgical planning whenever necessary. Although panoramic radiographs have shown significant differences, CBCT is more effective in pointing out differences between patients and a control group, thus showing it as an important tool for evaluation of Gaucher patients.
Authors:
R M Nobre; A L R Ribeiro; S M Alves-Junior; F M Tuji; M das G Rodrigues Pinheiro; L R Pinheiro; J J V Pinheiro
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dento maxillo facial radiology     Volume:  41     ISSN:  0250-832X     ISO Abbreviation:  Dentomaxillofac Radiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-18     Completed Date:  2012-12-04     Revised Date:  2013-10-09    
Medline Journal Info:
Nlm Unique ID:  7609576     Medline TA:  Dentomaxillofac Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  541-7     Citation Subset:  D    
Affiliation:
Department of Oral and Maxillofacial Pathology, Federal University of Para, Belem, Brazil. rmoutinho@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bone Diseases, Metabolic / radiography
Bone Marrow Diseases / radiography
Case-Control Studies
Child
Cone-Beam Computed Tomography
Female
Gaucher Disease / radiography*
Humans
Jaw Diseases / radiography*
Male
Mandibular Condyle / radiography
Mandibular Diseases / radiography
Maxillary Diseases / radiography
Maxillary Sinus / radiography
Nasal Mucosa / radiography
Radiography, Panoramic
Tooth Diseases / radiography*
Young Adult
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