Document Detail


Dentine phosphoproteins in gingival crevicular fluid during root resorption.
MedLine Citation:
PMID:  14994879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
External apical root resorption is a common, yet unexplained, phenomenon associated with orthodontic treatment. Available methods of clinical evaluation are radiographic. Biochemical assays offer the advantage of being non-invasive, as well as being diagnostic and potentially prognostic. The hypotheses are firstly that during the process of root resorption, organic matrix proteins are released into the gingival crevicular fluid (GCF) and, secondly, that there is a difference in the levels of these proteins between a group of patients with mild root resorption and a control group. GCF was collected from the permanent central incisors of untreated subjects (controls, n = 20), primary second molars with half of the root resorbed (primary group and positive controls, n = 20) and permanent central incisors with mild root resorption in patients undergoing active orthodontic treatment (orthodontic group, n = 20). Dentine phosphoproteins (DPP) were measured in the GCF using an enzyme-linked immunosorbent assay developed with DPP isolated from human first premolars and an antibody against rat incisor DPP. The primary group showed the highest levels of DPP in the GCF compared with the orthodontic (P = 0.296) and control (P = 0.001) groups. The orthodontic group showed elevated levels relative to the control group (P = 0.046). It is concluded that root resorption can be studied using a biochemical immunoassay and that this method can provide quantitative measurement of DPP in GCF.
Authors:
James Mah; Neelanjani Prasad
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of orthodontics     Volume:  26     ISSN:  0141-5387     ISO Abbreviation:  Eur J Orthod     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-03     Completed Date:  2004-03-25     Revised Date:  2010-02-05    
Medline Journal Info:
Nlm Unique ID:  7909010     Medline TA:  Eur J Orthod     Country:  England    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  D; IM    
Affiliation:
Division of Craniofacial Sciences and Therapeutics, University of Southern California, Los Angeles, California 90089-0641, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Animals
Biological Markers / analysis
Child
Dentin / metabolism
Extracellular Matrix Proteins
Female
Gingival Crevicular Fluid / chemistry*
Humans
Incisor / metabolism
Male
Molar / metabolism
Orthodontics, Corrective
Phosphoproteins / analysis*
Protein Precursors / analysis*
Rats
Root Resorption / metabolism*
Sialoglycoproteins / analysis*
Tooth, Deciduous / metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Extracellular Matrix Proteins; 0/Phosphoproteins; 0/Protein Precursors; 0/Sialoglycoproteins; 0/dentin sialophosphoprotein; 0/phosphophoryn

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